Evidence map›Paper›PMID 40340592›Full record

ArticleCirculation. Cardiovascular imaging2025

Characterization of Aortic Valve Stenosis by CT Angiography in a Diverse US Cohort.

Daniel Lorenzatti, Annalisa Filtz, Pamela Pina, Jolien Geers, Jake Gilman, Jonathan Daich, Paul Ippolito, Abdullah Aftab, Aldo L Schenone, Carlos A Gongora and 14 more

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In one paragraph

Article in Circulation. Cardiovascular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

24 authors.

Daniel Lorenzatti *Division of Cardiology, Montefiore Health System/Albert Einstein College of Medicine, Bronx, NY (D.L., A.F., J. Gilman, J.D., P.I., A.A., A.L.S., C.A.G., J.J., A.S., E.C.H., M.J.G., A.L., C.J.R., L.S.).ORCID 0000-0002-4467-167X
Annalisa Filtz *Division of Cardiology, Montefiore Health System/Albert Einstein College of Medicine, Bronx, NY (D.L., A.F., J. Gilman, J.D., P.I., A.A., A.L.S., C.A.G., J.J., A.S., E.C.H., M.J.G., A.L., C.J.R., L.S.).
Pamela PinaDepartment of Cardiology, Centro de Diagnóstico, Medicina Avanzada y Telemedicina (CEDIMAT), Santo Domingo, Dominican Republic (P. Pina).
Jolien GeersCedars-Sinai Heart Institute and Departments of Imaging and Medicine (J. Geers, D.S.B.), Cedars-Sinai Medical Center, Los Angeles, CA.ORCID 0000-0003-1109-5191
Jake GilmanDivision of Cardiology, Montefiore Health System/Albert Einstein College of Medicine, Bronx, NY (D.L., A.F., J. Gilman, J.D., P.I., A.A., A.L.S., C.A.G., J.J., A.S., E.C.H., M.J.G., A.L., C.J.R., L.S.).
Jonathan DaichDivision of Cardiology, Montefiore Health System/Albert Einstein College of Medicine, Bronx, NY (D.L., A.F., J. Gilman, J.D., P.I., A.A., A.L.S., C.A.G., J.J., A.S., E.C.H., M.J.G., A.L., C.J.R., L.S.).ORCID 0000-0002-2064-6437
Paul IppolitoDivision of Cardiology, Montefiore Health System/Albert Einstein College of Medicine, Bronx, NY (D.L., A.F., J. Gilman, J.D., P.I., A.A., A.L.S., C.A.G., J.J., A.S., E.C.H., M.J.G., A.L., C.J.R., L.S.).ORCID 0000-0002-1691-6852
Abdullah AftabDivision of Cardiology, Montefiore Health System/Albert Einstein College of Medicine, Bronx, NY (D.L., A.F., J. Gilman, J.D., P.I., A.A., A.L.S., C.A.G., J.J., A.S., E.C.H., M.J.G., A.L., C.J.R., L.S.).
Aldo L SchenoneDivision of Cardiology, Montefiore Health System/Albert Einstein College of Medicine, Bronx, NY (D.L., A.F., J. Gilman, J.D., P.I., A.A., A.L.S., C.A.G., J.J., A.S., E.C.H., M.J.G., A.L., C.J.R., L.S.).
Carlos A GongoraDivision of Cardiology, Montefiore Health System/Albert Einstein College of Medicine, Bronx, NY (D.L., A.F., J. Gilman, J.D., P.I., A.A., A.L.S., C.A.G., J.J., A.S., E.C.H., M.J.G., A.L., C.J.R., L.S.).
Justin JohannesenDivision of Cardiology, Montefiore Health System/Albert Einstein College of Medicine, Bronx, NY (D.L., A.F., J. Gilman, J.D., P.I., A.A., A.L.S., C.A.G., J.J., A.S., E.C.H., M.J.G., A.L., C.J.R., L.S.).
Andrea ScottiDivision of Cardiology, Montefiore Health System/Albert Einstein College of Medicine, Bronx, NY (D.L., A.F., J. Gilman, J.D., P.I., A.A., A.L.S., C.A.G., J.J., A.S., E.C.H., M.J.G., A.L., C.J.R., L.S.).ORCID 0000-0003-4731-4384
Edwin C HoDivision of Cardiology, Montefiore Health System/Albert Einstein College of Medicine, Bronx, NY (D.L., A.F., J. Gilman, J.D., P.I., A.A., A.L.S., C.A.G., J.J., A.S., E.C.H., M.J.G., A.L., C.J.R., L.S.).ORCID 0000-0002-5126-6314
Mario J GarciaDivision of Cardiology, Montefiore Health System/Albert Einstein College of Medicine, Bronx, NY (D.L., A.F., J. Gilman, J.D., P.I., A.A., A.L.S., C.A.G., J.J., A.S., E.C.H., M.J.G., A.L., C.J.R., L.S.).ORCID 0000-0002-7503-0285
Azeem LatibDivision of Cardiology, Montefiore Health System/Albert Einstein College of Medicine, Bronx, NY (D.L., A.F., J. Gilman, J.D., P.I., A.A., A.L.S., C.A.G., J.J., A.S., E.C.H., M.J.G., A.L., C.J.R., L.S.).ORCID 0000-0001-9035-343X
Carlos J RodriguezDivision of Cardiology, Montefiore Health System/Albert Einstein College of Medicine, Bronx, NY (D.L., A.F., J. Gilman, J.D., P.I., A.A., A.L.S., C.A.G., J.J., A.S., E.C.H., M.J.G., A.L., C.J.R., L.S.).ORCID 0000-0003-0860-9008
Daniel S BermanCedars-Sinai Heart Institute and Departments of Imaging and Medicine (J. Geers, D.S.B.), Cedars-Sinai Medical Center, Los Angeles, CA.ORCID 0000-0002-3793-9578
Marie-Annick ClavelInstitut Universitaire de Cardiologie et de Pneumologie, Université Laval, Quebec City, Quebec, Canada (M.-A.C., P. Pibarot).ORCID 0000-0002-8924-740X
Philippe PibarotInstitut Universitaire de Cardiologie et de Pneumologie, Université Laval, Quebec City, Quebec, Canada (M.-A.C., P. Pibarot).ORCID 0000-0002-3607-279X
Robert O BonowNorthwestern University Feinberg School of Medicine, Chicago, IL (R.O.B.).
Piotr J Slomkaand Biomedical Imaging Research Institute (P.J.S., D.D.), Cedars-Sinai Medical Center, Los Angeles, CA.ORCID 0000-0002-6110-938X
Marc R DweckCentre for Cardiovascular Science, The University of Edinburgh, United Kingdom (M.R.D.).ORCID 0000-0001-9847-5917
Damini Deyand Biomedical Imaging Research Institute (P.J.S., D.D.), Cedars-Sinai Medical Center, Los Angeles, CA.ORCID 0000-0003-2236-6970
Leandro SlipczukDivision of Cardiology, Montefiore Health System/Albert Einstein College of Medicine, Bronx, NY (D.L., A.F., J. Gilman, J.D., P.I., A.A., A.L.S., C.A.G., J.J., A.S., E.C.H., M.J.G., A.L., C.J.R., L.S.).ORCID 0000-0003-3091-3735

Funding

AI-enabled characterization of fibrocalcific aortic valve disease and inflammation from CT Angiography: Patient-specific outcome predictionR01HL175875 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Damini Dey · 2024 to 2026
$2.4M
NHLBI NIH HHS R01 HL175875
6 · The paper itself

Abstract

backgroundAortic stenosis (AS) involves calcific and fibrotic degeneration of the valve tissue. The only noninvasive method for evaluating both processes is contrast-enhanced computed tomography angiography. We aimed to explore the differences in aortic valve (AV) tissue composition across sex, race/ethnicity, and AS hemodynamic phenotype in US patients referred for transcatheter AV replacement planning.

methodsWe retrospectively analyzed symptomatic patients with AS who underwent computed tomography angiography for transcatheter AV replacement planning between 2015 and 2022. Using semi-automated software, we quantified the AV tissue composition by fibrotic, calcific, and fibro-calcific volumes, and the fibro-calcific ratio (fibrotic/calcific volume) as a measure of valve phenotype.

resultsThe study included 651 patients (mean age 84 years; 55% women) with 38% non-Hispanic (NH)-White, 27% Hispanic, and 13% NH-Black. Women had lower fibro-calcific (230 versus 293 mm³/cm²;

conclusionsPhenotypic differences in computed tomography angiography valve tissue composition exist in patients with AS referred for transcatheter AV replacement, with women and low-gradient AS showing a proportionally more fibrotic phenotype. NH-White women have the highest fibrotic tissue composition, and no differences are evident among men.

Indexed as

Aortic ValveAortic Valve StenosisCalcinosisComputed Tomography AngiographyAgedAged, 80 and overFemaleFibrosisHumansMalePredictive Value of TestsRetrospective StudiesSex FactorsTranscatheter Aortic Valve ReplacementUnited Statesaortic valveaortic valve stenosiscomputed tomography angiographyheart valve diseasesracial groupssex

Identifiers

PMID40340592
PMCPMC12178321

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