Evidence map›Paper›PMID 40340587›Full record

Trial reportGlobal health action2025

Patient perspectives on group problem management plus for adults with major depressive disorder in rural Malawi.

Owen Mwale, Caren Kasambala, Amruta Houde, Kondwani Mpinga, Waste Kayira, Michael Harawa, Myrrah Kamwiyo, Rachel Isaacs, Basimenye Nhlema, Todd Ruderman and 4 more

Registry-linked trialAbstract readClinical Trial, Phase IVRandomized Controlled Trial
In one paragraph

Trial report in Global health action, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04777006 (Integrating a Stepped Care Model of Screening and Treatment for Depression Into Malawi's National HIV Care Delivery Platform), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04777006 phase4completednot on this map

Integrating a Stepped Care Model of Screening and Treatment for Depression Into Malawi's National HIV Care Delivery Platform

TypeinterventionalSponsorRANDRan2021 to 2025Enrolled487ConditionsDepressive DisorderArmsProblem Management Plus, Antidepressant Therapy
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Owen MwaleAPZU, Partners In Health, Neno, Malawi.ORCID 0009-0000-2212-773X
Caren KasambalaAPZU, Partners In Health, Neno, Malawi.
Amruta HoudeMinistry of Health, Zomba Mental Hospital, Zomba, Malawi.
Kondwani MpingaAPZU, Partners In Health, Neno, Malawi.ORCID 0009-0001-9086-3234
Waste KayiraAPZU, Partners In Health, Neno, Malawi.
Michael HarawaAPZU, Partners In Health, Neno, Malawi.
Myrrah KamwiyoAPZU, Partners In Health, Neno, Malawi.
Rachel IsaacsMinistry of Health, Zomba Mental Hospital, Zomba, Malawi.ORCID 0000-0002-5962-9861
Basimenye NhlemaAPZU, Partners In Health, Neno, Malawi.ORCID 0009-0008-9838-0166
Todd RudermanAPZU, Partners In Health, Neno, Malawi.ORCID 0000-0002-6355-1649
Olive LiwimbiClinical Services, Ministry of Health, Lilongwe, Malawi.ORCID 0009-0007-3117-7668
Michael UdediHeadquarters, Partners In Health, Boston, MA, USA.ORCID 0000-0001-8769-4313
Ksakrad KellyMinistry of Health, Zomba Mental Hospital, Zomba, Malawi.
Ryan K McBainHealthcare Delivery, RAND Corporation, Washington, DC, USA.ORCID 0000-0003-0073-0348

Funding

Integrating a Stepped Care Model of Screening and Treatment for Depression into Malawi's National HIV Care Delivery PlatformR01MH117760 · NIMH · RAND CORPORATION · PI MCBAIN, RYAN K, WAGNER, GLENN JOHN · 2020 to 2024
$3.0M
NIMH NIH HHS R01 MH117760
6 · The paper itself

Abstract

backgroundMajor depressive disorder (MDD) frequently co-occurs with other medical conditions. Care integration and task shifting are two frameworks that may strengthen person-centered care among individuals with MDD and comorbid diagnoses, including for adults with limited access to healthcare resources living in rural settings within sub-Saharan Africa.

objectiveWe assessed the acceptability and feasibility of group psychotherapy (Problem Management Plus [PM+]) integrated into chronic healthcare services in Neno District, based on key informant (KI) interviews with clients who received PM+ services from local counselors.

methodsWe conducted in-depth interviews with 31 KIs, comprising adult patients participating in group PM+ in rural Malawi. The interview covered facets such as knowledge acquisition, logistical considerations for organizing PM+ sessions, selection of appropriate venues, session format, and overall perceived acceptability. Themes were identified through thematic content analysis.

resultsWe identified five emergent themes: limited prior awareness and understanding of MDD, positive elements of the PM+ service delivery model, patients' perceived effectiveness of PM+, logistical challenges with effectively engaging PM+, and positive views on acceptability of PM+. Findings revealed a strong appreciation and enthusiasm for PM+, although KIs noted areas for improvement - including lengthy travel times to receive PM+, limited compensation and privacy, and counselors arriving late.

conclusionInsights from clients underscore the potential utility of group PM+ as a task-shifted model of MDD care that can be integrated into existing service packages in resource-limited settings, as well as opportunities for improvements such as reducing travel time to care and identifying venues with greater client privacy.

trial registrationClinicalTrials.gov identifier: NCT04777006.

Indexed as

Major Depressive DisorderPsychotherapy, GroupAdultFemaleHumansInterviews as TopicMalawiMaleMiddle AgedPatient Acceptance of Health CareQualitative ResearchRural PopulationYoung Adultcare integrationDepressionkey informant interviewsmental healthpsychotherapytask shifting

Identifiers

PMID40340587
PMCPMC12068342

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.