Evidence map›Paper›PMID 40340446›Full record

ArticleInfection and immunity2025

Transdifferentiation of neutrophils facilitates the establishment of infection by

Madhurima Roy, Aniruddha Bagchi, Chaitali Karmakar, Mitali Chatterjee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Frontiers in immunology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Madhurima RoyDepartment of Pharmacology, Institute of Postgraduate Medical Education and Research (IPGME&R), Kolkata, India.ORCID 0000-0001-8808-7101
Aniruddha BagchiDepartment of Pharmacology, Institute of Postgraduate Medical Education and Research (IPGME&R), Kolkata, India.
Chaitali KarmakarDepartment of Pharmacology, Institute of Postgraduate Medical Education and Research (IPGME&R), Kolkata, India.
Mitali ChatterjeeDepartment of Pharmacology, Institute of Postgraduate Medical Education and Research (IPGME&R), Kolkata, India.

Funding

Indian Council of Medical Research 6/ 9-7(151)2017-ECD IIJC Bose Fellowship, Govt. of India JCB/2019/000043
6 · The paper itself

Abstract

Neutrophil transdifferentiation involves the acquisition of dendritic cell-like properties, challenging the traditional view of neutrophils being solely phagocytes. The presence of transdifferentiated neutrophils is established in Visceral Leishmaniasis, but not in its dermal sequel, Post Kala-azar Dermal Leishmaniasis. Accordingly, this study investigated the altered functionalities of neutrophils focusing on the acquisition of dendritic cell-like properties and its impact on infection establishment. In PKDL cases, immunophenotyping of neutrophil-dendritic cells (N-DC hybrids) was performed using flow cytometry, along with studying the status of N-DC hybrid inducing cytokines (TNF-α, IFN-γ) and growth factor (GM-CSF).

Indexed as

Cell TransdifferentiationLeishmania donovaniLeishmaniasis, VisceralNeutrophilsAdultApoptosisCytokinesDendritic CellsFemaleHumansMaleMiddle AgedPhagocytosisReactive Oxygen SpeciesCytokinesReactive Oxygen Speciesapoptosisneutrophil-dendritic cell (N-DC) hybridsphagocytosisPost Kala-azar Dermal Leishmaniasis (PKDL)reactive oxygen speciestransdifferentiation

Identifiers

PMID40340446
PMCPMC12150689

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.