Evidence map›Paper›PMID 40340444›Full record

ArticleApplied and environmental microbiology2025

7β-Hydroxysteroid dehydratase Hsh3 eliminates the 7-hydroxy group of the bile salt ursodeoxycholate during degradation by

Phil Richtsmeier, Ruslan Nedielkov, Malte Haring, Onur Yücel, Lea Elsner, Rebekka Herdis Lülf, Lars Wöhlbrand, Ralf Rabus, Heiko Moeller, Bodo Philipp and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied and environmental microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Phil RichtsmeierMicrobial Biotechnology and Ecology, Institute for Molecular Microbiology and Biotechnology, University of Münster, Münster, Germany.
Ruslan NedielkovInstitute for Chemistry, University of Potsdam, Potsdam, Germany.
Malte HaringMicrobial Biotechnology and Ecology, Institute for Molecular Microbiology and Biotechnology, University of Münster, Münster, Germany.
Onur YücelMicrobial Biotechnology and Ecology, Institute for Molecular Microbiology and Biotechnology, University of Münster, Münster, Germany.
Lea ElsnerMicrobial Biotechnology and Ecology, Institute for Molecular Microbiology and Biotechnology, University of Münster, Münster, Germany.
Rebekka Herdis LülfMicrobial Biotechnology and Ecology, Institute for Molecular Microbiology and Biotechnology, University of Münster, Münster, Germany.
Lars WöhlbrandGeneral and Molecular Microbiology, Institute for Chemistry and Biology of the Marine Environment (ICBM), Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany.
Ralf RabusGeneral and Molecular Microbiology, Institute for Chemistry and Biology of the Marine Environment (ICBM), Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany.ORCID 0000-0001-5536-431X
Heiko MoellerInstitute for Chemistry, University of Potsdam, Potsdam, Germany.
Bodo PhilippMicrobial Biotechnology and Ecology, Institute for Molecular Microbiology and Biotechnology, University of Münster, Münster, Germany.ORCID 0000-0002-6424-0770
Franziska Maria MuellerMicrobial Biotechnology and Ecology, Institute for Molecular Microbiology and Biotechnology, University of Münster, Münster, Germany.ORCID 0000-0002-0745-5847

Funding

Deutsche Forschungsgemeinschaft PH71/3-2, INST 211/646-1 FUGG
6 · The paper itself

Abstract

Bile salts are steroids with distinctive hydroxylation patterns that are produced and excreted by vertebrates. In contrast to common human bile salts, ursodeoxycholate (UDCA) has a 7-hydroxy group in β-configuration and is used in large amounts for the treatment of diverse gastrointestinal diseases. We isolated the 7β-hydroxysteroid dehydratase Hsh3 that is involved in UDCA degradation by

Indexed as

Bacterial ProteinsBile Acids and SaltsHydro-LyasesSphingomonadaceaeUrsodeoxycholic AcidBacterial ProteinsBile Acids and SaltsHydro-LyasesUrsodeoxycholic Acidhydroxysteroid dehydratasesteroid degradationsteroid transformationursodeoxycholate

Identifiers

PMID40340444
PMCPMC12175502

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.