Evidence map›Paper›PMID 40340440›Full record

ArticlemSphere2025

Genome content reorganization in the non-model ciliate

Ragib Ahsan, Xyrus X Maurer-Alcalá, Laura A Katz

Abstract read
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Ragib AhsanProgram in Organismic and Evolutionary Biology, University of Massachusetts Amherst, Amherst, Massachusetts, USA.ORCID 0000-0003-4550-9575
Xyrus X Maurer-AlcaláDivision of Invertebrate Zoology and Institute for Comparative Genomics, American Museum of Natural History, New York, New York, USA.ORCID 0000-0002-7499-9369
Laura A KatzProgram in Organismic and Evolutionary Biology, University of Massachusetts Amherst, Amherst, Massachusetts, USA.ORCID 0000-0002-9138-4702

Funding

Assessing evolutionary patterns in uncultivable ciliates and their microbiomes by combining single-cell transcriptomics and single-cell genomicsR15HG010409 · NHGRI · SMITH COLLEGE · PI KATZ, LAURA ALINE · 2019 to 2019
$400k
NHGRI NIH HHS R15 HG010409
6 · The paper itself

Abstract

Ciliates are a model lineage for studies of genome architecture given their unusual genome structures. All ciliates have both somatic macronuclei (MAC) and germline micronuclei (MIC), both of which develop from a zygotic nucleus following sex (i.e., conjugation). Nuclear developmental stages are not well documented among non-model ciliates, including IMPORTANCE: Ciliates are a clade of diverse single-celled eukaryotic microorganisms that contain at least one somatic macronucleus (MAC) and germline micronucleus (MIC) within each cell/organism. Ciliates rely on complex genome rearrangements to generate somatic genomes from a zygotic nucleus. However, the development of somatic nuclei has only been documented for a few model ciliate genera, including

Indexed as

Cell NucleusChromosomesCiliophoraDNA, ProtozoanGenome, ProtozoanMacronucleusIndolesIn Situ Hybridization, FluorescenceMicronucleus, GermlineMicroscopy, ConfocalDAPIDNA, ProtozoanIndoleschromosomesciliateconfocal imagingDAPIDNA contentFISHgenesgenome dynamicsmacronucleinuclear cyclesingle-celled microorganismstelomere

Identifiers

PMID40340440
PMCPMC12188737

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.