Evidence map›Paper›PMID 40340425›Full record

ReviewCirculation. Genomic and precision medicine2025

Data Interoperability and Harmonization in Cardiovascular Genomic and Precision Medicine.

C Anwar A Chahal, Fares Alahdab, Babken Asatryan, Daniel Addison, Nay Aung, Mina K Chung, Spiros Denaxas, Jessilyn Dunn, Jennifer L Hall, Nathalie Pamir and 3 more

Abstract readReview
In one paragraph

Review in Circulation. Genomic and precision medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

C Anwar A ChahalDepartment of Heart and Vascular, Center for Inherited Cardiovascular Diseases, WellSpan Health, York, PA (C.A.A.C.).ORCID 0000-0001-7825-8827
Fares AlahdabDepartments of Cardiology & Biomedical Informatics, Biostatistics, and Epidemiology, University of Missouri, Columbia (F.A.).ORCID 0000-0001-5481-696X
Babken AsatryanJohns Hopkins University, Baltimore, MD (B.A.).ORCID 0000-0002-0050-5717
Daniel AddisonDivision of Cardiovascular Medicine, Department of Medicine, Cardio-Oncology Program (D.A.) and.ORCID 0000-0002-9113-8333
Nay AungDepartment of Cardiology, Barts Heart Center, London, United Kingdom (C.A.A.C., N.A.).ORCID 0000-0001-5095-1611
Mina K ChungDepartments of Cardiovascular Medicine, Heart, Vascular & Thoracic Institute & Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, OH (M.K.C.).ORCID 0000-0002-7835-6045
Spiros DenaxasInstitute of Health Informatics, University College London, United Kingdom (S.D.).ORCID 0000-0001-9612-7791
Jessilyn DunnDepartment of Biomedical Engineering, Department of Biostatistics & Bioinformatics, Duke Clinical Research Institute, Duke University, Durham, NC (J.D.).ORCID 0000-0002-3241-8183
Jennifer L HallAmerican Heart Association, Dallas, TX (J.L.H.).ORCID 0000-0002-5103-5399
Nathalie PamirCenter for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland (N.P.).ORCID 0000-0002-2074-888X
David J SlotwinerHofstra School of Medicine, North Shore-Long Island Jewish Health System, New York, NY (D.J.S.).ORCID 0000-0002-4130-0419
Jose D VargasDepartment of Cardiology, Veterans Affairs Medical Center, Washington, DC (J.D.V.).
Antonis A ArmoundasCardiovascular Research Center, Massachusetts General Hospital, Boston (A.A.A.).ORCID 0000-0001-5006-1547

Funding

Novel patient biomarkers and mechanisms of TKI associated CardiotoxicityR01HL170038 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Daniel Addison · 2023 to 2026
$2.7M
Prevention and Treatment of Ventricular TachyarrhythmiasR01HL135335 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ARMOUNDAS, ANTONIS A · 2017 to 2020
$2.1M
Biomarker-guided optimization of transcutaneous vagal stimulation for atrial fibrillationR01HL161008 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Stavros Stavrakis · 2022 to 2026
$1.9M
A Medical-Grade Smart-Phone Based Monitoring System (Supplement)R21EB026164 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ARMOUNDAS, ANTONIS A · 2018 to 2020
$668k
Early Detection and Mechanisms of Cancer Immunotherapy Associated CardiotoxicityK23HL155890 · NHLBI · OHIO STATE UNIVERSITY · PI ADDISON, DANIEL · 2021 to 2024
$663k
Utility of Vagal Stimulation to Prevent the Onset of Ventricular ArrhythmiasR21HL137870 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ARMOUNDAS, ANTONIS A · 2017 to 2018
$468k
NHLBI NIH HHS K23 HL155890NHLBI NIH HHS R01 HL135335NHLBI NIH HHS R01 HL161008NHLBI NIH HHS R01 HL170038NHLBI NIH HHS R21 HL137870NIBIB NIH HHS R21 EB026164
6 · The paper itself

Abstract

Despite advances in cardiovascular care and improved outcomes, fragmented healthcare systems, nonequitable access to health care, and nonuniform and unbiased collection and access to healthcare data have exacerbated disparities in healthcare provision and further delayed the technological-enabled implementation of precision medicine. Precision medicine relies on a foundation of accurate and valid omics and phenomics that can be harnessed at scale from electronic health records. Big data approaches in noncardiovascular healthcare domains have helped improve efficiency and expedite the development of novel therapeutics; therefore, applying such an approach to cardiovascular precision medicine is an opportunity to further advance the field. Several endeavors, including the American Heart Association Precision Medicine platform and public-private partnerships (such as BigData@Heart in Europe), as well as cloud-based platforms, such as Terra used for the National Institutes of Health All of Us, are attempting to temporally and ontologically harmonize data. This state-of-the-art review summarizes best practices used in cardiovascular genomic and precision medicine and provides recommendations for systems' requirements that could enhance and accelerate the integration of these platforms.

Indexed as

Cardiovascular DiseasesGenomicsPrecision MedicineBig DataElectronic Health RecordsHumansbig dataelectronic health recordsnatural language processingphenomicstranslational research, biomedical

Identifiers

PMID40340425
PMCPMC12173165

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.