ArticleThe journal of physical chemistry. A2025
Serine Octamer Clusters Direct the Chirality of Peptides Formed in Water Microdroplets.
Article in The journal of physical chemistry. A, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Serine Octamer Substitution Reactions With α-Hydroxy Acids.Rapid communications in mass spectrometry : RCM · 2026Article
- Mass Spectrometry in Chiral Analysis and Synthesis.Chirality · 2026Article
- Depsipeptide Analogues of Gly-Ala-Gly: Proton Localization and Effects on Collision-Induced Dissociation.Journal of the American Society for Mass Spectrometry · 2026Article
- Mechanisms of ionization and of chemical reactions in charged microdroplets.Chemical science · 2025Review
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2 authors.
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Abstract
The chemistry underlying biological homochirality remains challenging. We propose that noncovalent clusters may have served as the means by which an enantiomeric excess of one amino acid could direct other racemic amino acids toward homochiral biochemistry. Serine has long been known to exhibit a chiral preference when clustering to form the octamer; here, we extend this finding by reporting the effects of a nonzero e.e. serine on the formation of noncovalent clusters with other amino acids as well as on the formation of peptides, their covalent condensation products. We show that (i) enantiopure serine directs racemic leucine and proline to enantioselective dipeptide formation in water microdroplets and (ii) likely intermediates are seen as the proline and leucine substituted serine octamer clusters. This work indicates the relevance of microdroplet sprays,
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