Evidence map›Paper›PMID 40340376›Full record

ArticleBiochemistry2025

Similar Rates of Second Electron Transfer and Single-Turnover Dehydroepiandrosterone Formation for Oxyferrous Human Cytochrome P450 17A1 (Steroid 17-Hydroxylase/17,20-lyase)-17-hydroxypregnenolone Complex with Either Human Cytochrome P450-Oxidoreductase or Human Cytochrome

Sang-Choul Im, Hwei-Ming Peng, Lucy Waskell, Richard J Auchus

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sang-Choul ImDivision of Metabolism, Endocrinology, & Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
Hwei-Ming PengDivision of Metabolism, Endocrinology, & Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
Lucy WaskellDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Richard J AuchusDivision of Metabolism, Endocrinology, & Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0001-6815-6181

Funding

Activation of androgen biosynthesis and drug metabolism by cytochrome b5R01GM086596 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI RICHARD J. AUCHUS · 2009 to 2026
$4.8M
Microsomal Cytochromes P450 and their Interactions with their Redox PartnersR01GM094209 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WASKELL, LUCY A · 2011 to 2014
$1.5M
NIGMS NIH HHS R01 GM086596NIGMS NIH HHS R01 GM094209
6 · The paper itself

Abstract

The 17-hydroxylase and 17,20-lyase activities of cytochrome P450 17A1 are required for androgen biosynthesis, which is the target of the prostate-cancer drug abiraterone acetate. Cytochrome

Indexed as

17-alpha-HydroxypregnenoloneCytochromes b5DehydroepiandrosteroneNADPH-Ferrihemoprotein ReductaseSteroid 17-alpha-HydroxylaseCytochrome P-450 Enzyme SystemElectron TransportHumansKineticsOxidation-ReductionOxygen17-alpha-HydroxypregnenoloneCYP17A1 protein, humanCytochrome P-450 Enzyme SystemCytochromes b5DehydroepiandrosteroneNADPH-Ferrihemoprotein ReductaseOxygenPOR protein, humanSteroid 17-alpha-Hydroxylase

Identifiers

PMID40340376
PMCPMC13307519

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.