Evidence map›Paper›PMID 40340313›Full record

ArticleACS chemical biology2025

Serendipitous and Systematic Chemoproteomic Discovery of MBLAC2, HINT1, and NME1-4 Inhibitors from Histone Deacetylase-Targeting Pharmacophores.

Severin Lechner, Shuyao Sha, Jigar Paras Sethiya, Patrycja Szczupak, Rafal Dolot, Santosh Lomada, Amirhossein Sakhteman, Johanna Tushaus, Polina Prokofeva, Michael Krauss and 11 more

Abstract read
In one paragraph

Article in ACS chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Severin LechnerChair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising 85354, Germany.ORCID 0000-0003-2297-9208
Shuyao ShaChair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising 85354, Germany.
Jigar Paras SethiyaDepartment of Medicinal Chemistry, University of Minnesota College of Pharmacy, Minneapolis, Minnesota 55414, United States.
Patrycja SzczupakDivision of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Łódź 90-363, Poland.
Rafal DolotDivision of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Łódź 90-363, Poland.
Santosh LomadaExperimental Pharmacology Mannheim, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Str. 13-17, Mannheim 68167, Germany.
Amirhossein SakhtemanChair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising 85354, Germany.
Johanna TushausChair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising 85354, Germany.
Polina ProkofevaChair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising 85354, Germany.
Michael KraussDepartment of Biology, Chemistry, Pharmacy, Leibniz Institute fur Molecular Pharmacologie, Robert-Roessle-Strasse 10, Berlin 13125, Germany.
Ferdinand BreuDepartment of Pharmacy, Center for Drug Research, Ludwig-Maximilians University Munich, Munich 81377, Germany.
Katharina VögerlDepartment of Pharmacy, Center for Drug Research, Ludwig-Maximilians University Munich, Munich 81377, Germany.
Martin MorgensternDepartment of Pharmacy, Center for Drug Research, Ludwig-Maximilians University Munich, Munich 81377, Germany.
German Mouse Clinic Consortium
Martin Hrabě de AngelisGerman Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics, Neuherberg 85764, Germany.
Volker HauckeDepartment of Biology, Chemistry, Pharmacy, Leibniz Institute fur Molecular Pharmacologie, Robert-Roessle-Strasse 10, Berlin 13125, Germany.
Thomas WielandExperimental Pharmacology Mannheim, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Str. 13-17, Mannheim 68167, Germany.
Carston WagnerDepartment of Medicinal Chemistry, University of Minnesota College of Pharmacy, Minneapolis, Minnesota 55414, United States.ORCID 0000-0001-7927-719X
Guillaume MédardChair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising 85354, Germany.ORCID 0000-0002-4782-4029
Franz BracherDepartment of Pharmacy, Center for Drug Research, Ludwig-Maximilians University Munich, Munich 81377, Germany.
Bernhard KusterChair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising 85354, Germany.ORCID 0000-0002-9094-1677

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metalloenzyme inhibitors often incorporate a hydroxamic acid moiety to bind the bivalent metal ion cofactor within the enzyme's active site. Recently, inhibitors of Zn

Indexed as

Histone Deacetylase InhibitorsHistone DeacetylasesNerve Tissue ProteinsDrug DiscoveryHumansHydroxamic AcidsProteomicsHINT1 protein, humanHistone Deacetylase InhibitorsHistone DeacetylasesHydroxamic AcidsNerve Tissue Proteins

Identifiers

PMID40340313
PMCPMC12186257

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.