Evidence map›Paper›PMID 40339582›Full record

ArticleStructure (London, England : 1993)2025

The YEATS domain is a selective reader of histone methacrylation.

Dustin C Becht, Jiabao Song, Karthik Selvam, Kejun Yin, Weizhi Bai, Yingming Zhao, Ronghu Wu, Y George Zheng, Tatiana G Kutateladze

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Structure (London, England : 1993), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Discovery and Profiling of Protein CysteineMolecules (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dustin C BechtDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Jiabao SongDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602, USA.
Karthik SelvamDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Kejun YinSchool of Chemistry and Biochemistry and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Weizhi BaiDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602, USA.
Yingming ZhaoBen May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA.
Ronghu WuSchool of Chemistry and Biochemistry and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Y George ZhengDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602, USA. Electronic address: yzheng@uga.edu.
Tatiana G KutateladzeDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: tatiana.kutateladze@cuanschutz.edu.

Funding

Histone lactylation pathway in hair cycle: deacylases and their protein targetsR01AR078555 · NIAMS · UNIVERSITY OF CHICAGO · PI LIN, HENING, ZHAO, YINGMING · 2021 to 2025
$3.3M
Lactate production by tumor associated macrophages promotes tumorigenesisR01CA251677 · NCI · UNIVERSITY OF CHICAGO · PI BECKER, LEV, ZHAO, YINGMING · 2021 to 2025
$2.8M
Targeting acetylated histone H4 by MLL4R01AG067664 · NIA · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2021 to 2025
$2.1M
12 T FTICR-MS System for the Analysis of MetabolitesS10OD025118 · OD · UNIVERSITY OF GEORGIA · PI AMSTER, I JONATHAN · 2018 to 2018
$2.0M
Molecular analysis of ASH1LR01CA252707 · NCI · UNIVERSITY OF COLORADO DENVER · PI TATIANA G KUTATELADZE · 2020 to 2026
$1.9M
The role of JADE in HBO complexesR01HL151334 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2020 to 2023
$1.8M
Mechanism and Inhibition of Protein MethylationR35GM149230 · NIGMS · UNIVERSITY OF GEORGIA · PI Y. George Zheng · 2023 to 2026
$1.5M
Targeting acetylated histone H4 by MLL4R56AG067664 · NIA · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2020 to 2020
$512k
NCI NIH HHS R01 CA251677NCI NIH HHS R01 CA252707NHLBI NIH HHS R01 HL151334NIAMS NIH HHS R01 AR078555NIA NIH HHS R01 AG067664NIA NIH HHS R56 AG067664NIGMS NIH HHS R35 GM149230NIH HHS S10 OD025118
6 · The paper itself

Abstract

Metabolically regulated lysine acylation modifications in proteins play a major role in epigenetic processes and cellular homeostasis. A new type of histone acylation, lysine methacrylation, has recently been identified but remains poorly characterized. Here, we show that lysine methacrylation can be generated through metabolism of sodium methacrylate and enzymatically removed in cells, and that the YEATS domain but not bromodomain recognizes this modification. Structural and biochemical analyses reveal the π-π-π-stacking mechanism for binding of the YEATS domain of ENL to methacrylated histone H3K18 (H3K18mc). Using mass spectrometry proteomics, we demonstrate that methacrylate induces global methacrylation of a set of proteins that differs from the set of methacrylated proteins associated with valine metabolism. These findings suggest that high levels of methacrylate may potentially perturb cellular functions of these proteins by altering protein methacrylation profiles.

Indexed as

HistonesMethacrylatesSaccharomyces cerevisiae ProteinsTranscription FactorsAcylationHumansLysineModels, MolecularProtein BindingProtein DomainsProtein Processing, Post-TranslationalHistonesLysineMethacrylatesSaccharomyces cerevisiae ProteinsTranscription FactorsacetylationbromodomainepigeneticmethacrylationPTMYEATS

Identifiers

PMID40339582
PMCPMC12227292

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.