Evidence map›Paper›PMID 40339567›Full record

ArticleNeuron2025

Human pain neuroscience and the next generation of pain therapeutics.

Bryan A Copits, Michele Curatolo, Patrick M Dougherty, Robert W Gereau, Wenqin Luo, Maryann Martone, Hakan Olausson, Theodore J Price, William Renthal, Clifford J Woolf and 2 more

Abstract read
In one paragraph

Article in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. A Reference Atlas of the Human Dorsal Root Ganglion.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bryan A CopitsWashington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Michele CuratoloDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98195, USA.
Patrick M DoughertyDepartment of Pain Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Robert W GereauWashington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: gereaur@wustl.edu.
Wenqin LuoDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: luow@pennmedicine.upenn.edu.
Maryann MartoneDepartment of Neuroscience, University of California, San Diego, CA 92093, USA.
Hakan OlaussonDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Theodore J PriceCenter for Advanced Pain Studies and Department of Neuroscience, University of Texas at Dallas, Richardson, TX 75080, USA. Electronic address: theodore.price@utdallas.edu.
William RenthalDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: wrenthal@bwh.harvard.edu.
Clifford J WoolfF.M. Kirby Neurobiology Center and Department of Neurobiology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Guoyan ZhaoDepartment of Genetics and Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
NIH PRECISION Human Pain Network

Funding

Spatial Core (Moffit)U19NS130617 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI Jeffrey Moffitt · 2022 to 2026
$15.5M
Multi-omics peripheral nerve atlas enables fine-mapping of pain molecular phenotypesU19NS130607 · NINDS · WASHINGTON UNIVERSITY · PI Robert W Gereau · 2022 to 2026
$14.0M
Mechanistic underpinnings of chronic low back painU19NS130608 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI Michele Curatolo, Patrick M Dougherty · 2022 to 2026
$13.6M
The Penn Human Precision Pain Center (HPPC): Discovery and Functional Evaluation of Human Primary Somatosensory Neuron Types at Normal and Chronic Pain ConditionsU19NS135528 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Wenqin Luo · 2023 to 2026
$11.2M
UW Core Center for Clinical Research of Musculoskeletal ConditionsP30AR072572 · NIAMS · UNIVERSITY OF WASHINGTON · PI JEFFREY G JARVIK, Pradeep Suri · 2017 to 2026
$8.3M
Meaningful data integration, visualization and distribution for Human Pain Associated Genes & Cells DatasetsU24NS135547 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Peter John Hunter, MARYANN E MARTONE · 2023 to 2026
$5.9M
NIAMS NIH HHS P30 AR072572NINDS NIH HHS U19 NS130607NINDS NIH HHS U19 NS130608NINDS NIH HHS U19 NS130617NINDS NIH HHS U19 NS135528NINDS NIH HHS U24 NS135547
6 · The paper itself

Abstract

The recent approval of suzetrigine for acute pain treatment highlights both the success of targeting peripheral sensory neurons for pain management and the potential of developing new pain therapies primarily in human-based systems. To realize this transformative potential, further research into somatosensation and pain neuroimmunology in human systems is essential.

Indexed as

AnalgesicsNeurosciencesPainPain ManagementAnimalsHumansSensory Receptor CellsAnalgesics

Identifiers

PMID40339567
PMCPMC12279253

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.