ReviewOral oncology2025
Defining response-adapted surgery after neoadjuvant therapy in oral cavity cancer.
Review in Oral oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Head and neck related quality of life following glossectomy among tongue cancer patients: a systematic review and meta-analysis.Oral and maxillofacial surgery · 2025Pooled it
- Integrating Immunotherapy Into Head and Neck Surgery: Bridging Tumor Biology to Perioperative Decision-Making, a Review.Head & neck · 2026Review
- Role of micronutrition in patients with oral cancer and nutritional intervention strategies.Frontiers in nutrition · 2025Review
- Adjuvant radiotherapy for patients with clinical T3-4 oral and oropharyngeal cancer who achieved major pathologic response after neoadjuvant immunochemotherapy and surgery: a propensity score-matched retrospective study.Frontiers in immunology · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundResponse-adapted surgery in oncology refers tosurgical planning that considers a patient's response to neoadjuvant therapy. To advance the study of this strategy and for integration into routine clinical care, rigorous documentation of any response-adapted changes in surgery performed is needed. METHODS AND
resultsWe searched the medical literature and identified a gap in research into response-adapted surgery. We set out to describe a classification for documentation of the proposed resection at initial presentation and following neoadjuvant treatment at time of resection of locoregionally advanced oral cavity cancers. We based this classification upon the surgical anatomy of the oral cavity. We have divided the adaptations into structures resected, exposure lymph node basin management, and reconstruction. Using expert opinion, we developed the surgical morbidity score. This classification was reviewed and endorsed by the head and neck disease management team at our institution for use in all patients with oral cavity cancer treated with neoadjuvant strategies.
conclusionsThe proposed classification will allow for the use of consistent terminology to define response-adapted surgery in patients with locoregionally advanced oral cavity cancer treated with a neoadjuvant approach prior to definitive surgery. This uniform classification will facilitate improved communication between head and neck oncologists, comparison between published studies, and consistency in the development of clinical trial endpoints incorporating organ preservation as a vital health-related quality of life outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.