Evidence map›Paper›PMID 40339327›Full record

ReviewCurrent opinion in structural biology2025

Deciphering the language of mingling lipids and proteins.

Michael Overduin, Rakesh Bhat, Thibaud Dieudonné, Peijun Zhang, Troy A Kervin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in structural biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michael OverduinDepartment of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton Canada; Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS, Gif-sur-Yvette, France. Electronic address: overduin@ualberta.ca.
Rakesh BhatDepartment of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton Canada.
Thibaud DieudonnéInstitute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS, Gif-sur-Yvette, France.
Peijun ZhangDivision of Structural Biology, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Troy A KervinDivision of Structural Biology, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Funding

Project 3. IntegrationU54AI170791 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Zandrea Ambrose · 2022 to 2026
$30.6M
Correlative cryoET of the HIV-1 integration targeting in native T-lymphocytesR21AI184080 · NIAID · UNIVERSITY OF OXFORD · PI ZHANG, PEIJUN · 2024 to 2025
$285k
NIAID NIH HHS R21 AI184080NIAID NIH HHS U54 AI170791
6 · The paper itself

Abstract

Each cell possesses a genetic and a proteolipid code that together convey molecular information in a perpetual cycle. One element of this cycle is the recognition of lipids that work together to specify subcellular locations for biochemical activity. These "lipidons" are now being resolved in protein structures from eukaryotic plasma membranes, endosomes, mitochondria, prokaryotes, and viruses with technologies like in situ cryo-electron imaging and membrane-active polymers. This adds to an expanding catalogue of codified protein-lipid interactions that are recontextualizing cell biology and drug discovery.

Indexed as

Lipid MetabolismLipidsProteinsAnimalsHumansLipidsProteins

Identifiers

PMID40339327
PMCPMC12408116

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.