Evidence map›Paper›PMID 40339174›Full record

ReviewInternational braz j urol : official journal of the Brazilian Society of Urology

Management of Small Renal Masses: Literature and Guidelines Review.

Antonio Silvestri, Filippo Gavi, Maria Chiara Sighinolfi, Simone Assumma, Enrico Panio, Daniele Fettucciari, Giuseppe Pallotta, Or Schubert, Cristina Carerj, Mauro Ragonese and 6 more

Abstract readReview
In one paragraph

Review in International braz j urol : official journal of the Brazilian Society of Urology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Review
  7. Article
  8. Article
  9. Article
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  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Arterial Embolization versus Robotic Partial Nephrectomy for the Treatment of Renal Angiomyolipomas.International braz j urol : official journal of the Brazilian Society of Urology
    Article
  17. Article
  18. Robot-Assisted Partial Nephrectomy is the Hot Topic in this Number of International Brazilian Journal of Urology.International braz j urol : official journal of the Brazilian Society of Urology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Antonio SilvestriDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
Filippo GaviDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
Maria Chiara SighinolfiDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
Simone AssummaDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
Enrico PanioDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
Daniele FettucciariDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
Giuseppe PallottaDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
Or SchubertDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
Cristina CarerjDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
Mauro RagoneseDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
Pierluigi RussoDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
Riccardo BientinesiDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
Nazario FoschiDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
Chiara CiccareseDepartment of Oncology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
Roberto IacovelliDepartment of Oncology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
Bernardo RoccoDepartment of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal cell carcinoma (RCC) ranks among the most prevalent malignancies worldwide, with a rising incidence attributed largely to the incidental detection of small renal masses (SRMs ≤ 4 cm) through widespread abdominal imaging. Historically managed with radical nephrectomy, treatment of SRMs has evolved significantly over recent decades. Partial nephrectomy has become the standard surgical approach, while active surveillance (AS) has emerged as a viable alternative for select patients, particularly those with comorbidities or limited life expectancy. AS involves serial imaging to monitor tumor progression, reserving intervention for signs of clinical advancement. This review synthesizes oncological outcomes and current management strategies for SRMs, comparing AS with immediate intervention. A comprehensive literature search (2005-2024) was performed across PubMed, Web of Science, and Scopus, complemented by an analysis of major international guidelines (EAU, AUA, ESMO, CUA, and Latin American Renal Cancer Group). All guidelines support AS for selected patients with cT1a tumors, though criteria vary. The AUA limits AS to tumors <2 cm, while only its guidelines define clear triggers for transitioning from AS to treatment. Imaging surveillance intervals and biopsy indications also differ, with broader support for renal mass biopsy prior to ablation but more selective use during AS. This review underscores the importance of individualized decision-making in SRM management and highlights areas of consensus and divergence among contemporary guidelines.

Indexed as

Carcinoma, Renal CellKidney NeoplasmsPractice Guidelines as TopicHumansNephrectomyWatchful WaitingAdenocarcinoma, Clear CellKidney NeoplasmsWatchful Waiting

Identifiers

PMID40339174
PMCPMC12539897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.