ArticleSchizophrenia bulletin2025
Enhancing Coordinated Specialty Care Through Early Detection: Impact of Reduced Duration of Untreated Psychosis.
Article in Schizophrenia bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Clusters of social and substance use-related risks are associated with the duration of untreated psychosis.Psychological medicine · 2026Article
- Targeting the Roots of Psychosis: The Role of Aberrant Salience.Pediatric reports · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
background and hypothesisEarly intervention can improve outcomes for individuals with first-episode psychosis (FEP). We hypothesized that an early detection campaign (ED) targeting the duration of untreated psychosis (DUP) can significantly improve functional outcomes in coordinated specialty care (CSC) patients. STUDY
designFunctional outcomes were compared for FEP patients enrolled from 2014 to 2019 in 2 CSCs: Specialized treatment early in psychosis (STEP), which implemented a 4-year ED campaign, and the prevention and recovery in early psychosis (PREP) clinic, which maintained usual detection practices. The relationship between DUP-Total (time from psychosis onset to CSC enrollment) with global assessment of functioning (GAF) and quality of life (QoL) scores at 6 and 12 months was assessed. Mediation analyses explored the contributions of DUP-Demand (time from psychosis onset to the first use of antipsychotic medication) and DUP-Supply (time from the first use of antipsychotic medication to CSC enrollment). STUDY
resultsShorter DUP-total was associated with higher GAF and QoL scores, particularly at 6 months. STEP patients showed significantly greater improvements in GAF (12.2 points higher at 6 months, P < .0001) and QoL (6.8 points higher at 6 months, P = .03) compared to PREP. Mediation analyses revealed that DUP-Supply, rather than DUP-Demand, was the primary driver of these improvements at 6 months, explaining 36% of the QoL difference between clinics.
conclusionsShorter DUP accelerates functional recovery, particularly in the first 6 months of CSC. Reducing DUP-Supply is critical for maximizing the benefits of early intervention. Streamlined referral and intake processes should be prioritized to enhance recovery outcomes.
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