Evidence map›Paper›PMID 40339134›Full record

ArticleThe Journal of clinical endocrinology and metabolism2025

Associations of Sleep Health and Metabolic Syndrome Severity in Black Individuals: The Jackson Heart Sleep Study.

Daisy Duan, Jonathan C Jun, Dayna A Johnson, Rexford S Ahima, Jayandra J Himali, Alain G Bertoni, Susan Redline, Justin B Echouffo-Tcheugui

Erratum issuedAbstract read
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Daisy DuanDivision of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.ORCID 0000-0002-4392-3206
Jonathan C JunDivision of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Dayna A JohnsonDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Rexford S AhimaDivision of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Jayandra J HimaliGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Alain G BertoniDivision of Public Health Sciences, Wake Forest University School of Medicine, Winson-Salem, NC 27101, USA.ORCID 0000-0002-7503-6273
Susan RedlineDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-6585-1610
Justin B Echouffo-TcheuguiDivision of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.ORCID 0000-0002-8460-1617

Funding

Contributions of sleep to preclinical and clinical Alzheimer's diseaseR01AG062531 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HIMALI, JAYANDRA JUNG, PASE, MATTHEW · 2020 to 2023
$3.1M
Sleep-Disordered Breathing and Risk for CVD and Stroke in the Jackson Heart StudyR01HL110068 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI REDLINE, SUSAN S., WILSON, JAMES GRAHAM · 2012 to 2015
$2.9M
Metabolic Effects of Circadian-Based Dinner TimeK23DK133690 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Daisy Duan · 2022 to 2026
$1.0M
Establishing the Pathways Between Diabetes and Cardiac Dysfunction: Epidemiology, Biomarkers, and ImagingK23HL153774 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ECHOUFFO TCHEUGUI, JUSTIN BASILE · 2020 to 2024
$991k
National Institute for Minority Health and Health DisparitiesNHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS R01HL110068NIA NIH HHS R01 AG062531NIDDK NIH HHS K23 DK133690NIH HHS K23DK133690NIH HHS K23HL153774NIMHD NIH HHS HHSN268201800013I
6 · The paper itself

Abstract

contextThe influence of sleep and circadian-related factors on metabolic outcomes among Black Americans are under-studied, despite the disparities in both metabolic and sleep health in this population.

objectiveThis work aimed to investigate the relationship between domains of sleep and metabolic dysfunction severity in Black individuals.

methodsWe conducted a cross-sectional analysis of the Jackson Heart Sleep Study (2012-2016), using logistic regression to assess the associations between actigraphy parameters (sleep timing, duration and regularity, continuity) and severe metabolic syndrome (MetS), defined as the highest tertile of a validated sex-, race-, and ethnicity-specific MetS severity Z score. Models were adjusted for age, socioeconomic factors, physical activity, smoking, alcohol use, and moderate to severe obstructive sleep apnea.

resultsAmong 754 participants (mean age 63 ± 11 years, 66% women, mean body mass index 31.8 ± 6.8), mean sleep onset was 23:10 ± 1:24 (hh:mm), mean sleep duration was 6.7 ± 1.1 hour, median sleep maintenance efficiency was 88.9% (interquartile range [IQR], 85.7-91.5), and median sleep fragmentation index was 28.3% (IQR, 23.2-34). In adjusted models, each 1-hour later in mid-sleep time was associated with 14% (95% CI, 1.01-1.30) higher odds of severe MetS and each 1-hour increase in sleep duration variability was associated with 34% (95% CI, 1.01-1.77) higher odds. Each 1% decrease in sleep maintenance efficiency was associated with 5% (95% CI, 0.92-0.98) higher odds of having severe MetS, and each 1% increase in sleep fragmentation index was associated with 2% (95% CI, 1.01-1.04) higher odds.

conclusionLater sleep timing, irregular sleep duration, and poor sleep continuity were associated with more severe metabolic dysfunction in Black individuals, highlighting the importance of sleep health, beyond sleep duration, on metabolic health.

Indexed as

Black or African AmericanMetabolic SyndromeSleepSleep Wake DisordersActigraphyAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedSeverity of Illness IndexBlack Americanscircadian rhythmsmetabolic syndromesleep

Identifiers

PMID40339134
PMCPMC12342389

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.