Evidence map›Paper›PMID 40339129›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Differential elimination of marked sex chromosomes enables production of nontransgenic male mosquitoes in a single strain.

Austin Compton, Atashi Sharma, Melanie Hempel, Azadeh Aryan, James K Biedler, Mark B Potters, Karthikeyan Chandrasegaran, Clément Vinauger, Zhijian Tu

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Austin Compton *Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061.
Atashi Sharma *Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061.
Melanie Hempel *Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061.ORCID 0009-0006-5517-4085
Azadeh AryanDepartment of Biochemistry, Virginia Tech, Blacksburg, VA 24061.ORCID 0000-0001-6469-8573
James K BiedlerDepartment of Biochemistry, Virginia Tech, Blacksburg, VA 24061.ORCID 0000-0003-2612-0038
Mark B PottersDepartment of Biochemistry, Virginia Tech, Blacksburg, VA 24061.ORCID 0009-0009-9983-0031
Karthikeyan ChandrasegaranDepartment of Entomology, University of California at Riverside, Riverside, CA 92521.ORCID 0000-0001-8262-1510
Clément VinaugerDepartment of Biochemistry, Virginia Tech, Blacksburg, VA 24061.
Zhijian TuDepartment of Biochemistry, Virginia Tech, Blacksburg, VA 24061.ORCID 0000-0003-4227-3819

Funding

Sex ratio distortion in Aedes aegyptiR01AI157491 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI TU, ZHIJIAN JAKE · 2020 to 2024
$3.1M
Guy1-conferred female lethality: mechanism and application for mosquito controlR01AI121284 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI TU, ZHIJIAN JAKE · 2016 to 2020
$2.0M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI121284HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI157491NIAID NIH HHS R01 AI121284NIAID NIH HHS R01 AI157491RWJF | Robert Wood Johnson Foundation Health Policy Fellows (RWJF) No numberVT | Virginia Agricultural Experiment Station, Virginia Polytechnic Institute and State University (VAES) No number
6 · The paper itself

Abstract

Diverse genetic strategies are being pursued to control mosquito-borne infectious diseases. These strategies often rely on the release of nonbiting males to either reduce the target mosquito population or render them resistant to pathogens. Male-only releases are important as any contaminating females can bite and potentially transmit pathogens. Despite significant efforts, it remains a major bottleneck to reliably and efficiently separate males from females, especially when nontransgenic males are preferred. In the yellow fever mosquito

Indexed as

AedesSex ChromosomesAnimalsAnimals, Genetically ModifiedFemaleMaleMosquito Vectorshomomorphic sex chromosomemosquito controlrecessive lethalsex-separationsterile insect technique

Identifiers

PMID40339129
PMCPMC12087967

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.