ArticleProceedings of the National Academy of Sciences of the United States of America2025
Circadian clock-gated cell renewal controls time-dependent changes in taste sensitivity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- The circadian architecture of tumor immunity: mechanistic insights and treatment strategies.Biomarker research · 2026Review
- Converging Signaling Networks Drive Taste Bud Morphogenesis, Turnover, and Regeneration.International journal of molecular sciences · 2026Review
- The oral immune and inflammatory network under circadian clock control.Frontiers in immunology · 2026Review
- A bittersweet relationship between the cell cycle, circadian clock, and diurnal fluctuations in taste.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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Abstract
Circadian regulation of the cell cycle progression generates a diurnal supply of newborn cells to replace those lost in organs and tissues. In this study, we analyzed circadian time-dependent changes in cell types within the mouse tongue epithelium. Using single-cell RNA sequencing, we observed circadian time-dependent changes in the populations of stem/progenitor cells and the differentiated cells in mice tongues. Notably, we observed time-dependent changes in the type II taste cell population, which were abolished by ablation of taste bud stem cells, thereby inhibiting cell proliferation within the taste cell population. Through experiments with taste bud organoids (TBOs), we found a 24-h cell cycle period, which was disrupted by the knockdown of the core-clock gene
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