Evidence map›Paper›PMID 40339108›Full record

Observational studyThe Journal of infectious diseases2025

Wastewater Measures of SARS-CoV-2 Accurately Predict Frequency of Symptomatic Infections in the Community.

Charles R Doss, Mark J Osborn, Stacey Stark, Joshua Rhein, Jacalynn Donkersgoed, Donna Budde, Shannon Champeau, Carolyn Meyer, Mason Hayden, Laura Landini and 5 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Charles R DossSchool of Statistics, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0003-1364-5222
Mark J OsbornDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0003-1790-0841
Stacey StarkU-Spatial, Research Computing, University of Minnesota, Duluth, Minnesota.
Joshua RheinDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0002-0480-9646
Jacalynn DonkersgoedOffice of Employee Occupational Health and Safety, Fairview Health Services, Minneapolis, Minnesota.
Donna BuddeOffice of Employee Occupational Health and Safety, Fairview Health Services, Minneapolis, Minnesota.
Shannon ChampeauDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Carolyn MeyerDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Mason HaydenDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Laura LandiniDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Difan OuyangSchool of Statistics, University of Minnesota, Minneapolis, Minnesota.
Lappui ChungSchool of Statistics, University of Minnesota, Minneapolis, Minnesota.
Yi TangSchool of Public Administration, University of New Mexico, Albuquerque, New Mexico.
Sara VetterMinnesota Department of Public Health, Saint Paul, Minnesota.
Timothy W SchackerDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0002-2451-9937

Funding

Skin-targeted Cell Therapy for Recessive Dystrophic Epidermolysis BullosaR01AR063070 · NIAMS · UNIVERSITY OF MINNESOTA · PI Mark J Osborn, Jakub Tolar · 2013 to 2026
$4.5M
CDC HHS 00110343CDC HHS 00110450Minnesota Department of HealthNIAMS NIH HHS R01 AR063070
6 · The paper itself

Abstract

backgroundWidespread immunity through vaccination or natural infection has altered the predictive ability of wastewater for hospitalization and mortality.

methodsBetween January 2022 and August 2024, we conducted a longitudinal observational study that aimed to examine the correlation between symptomatic COVID-19 in health care employees and SARS-CoV-2 wastewater community levels. Wastewater was analyzed by quantitative reverse transcription polymerase chain reaction for detection of SARS-CoV-2. The Fairview Employee Occupational Health office provided deidentified data.

resultsWe collected 215 wastewater samples from the Twin Cities Wastewater Treatment Plant over a 32-month interval. Over that period, there were 6879 positive SARS-CoV-2 test results reported to Fairview Employee Health from individuals who lived in the wastewater catchment area. We found that SARS-CoV-2 levels in wastewater accurately predicted the subsequent COVID-19 case count the following week in the community (P = .001).

conclusionsThese data demonstrate the utility of SARS-CoV-2 wastewater surveillance as it accurately predicts the frequency of symptomatic infection in the community.

Indexed as

COVID-19SARS-CoV-2WastewaterFemaleHealth PersonnelHumansLongitudinal StudiesMaleMiddle AgedWastewaterCOVID-19polymerase chain reactionpredictive modelSARS-CoV-2wastewater

Identifiers

PMID40339108
PMCPMC12455328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.