Evidence map›Paper›PMID 40339062›Full record

ArticleACS infectious diseases2025

Versatile Imidazole Scaffold with Potent Activity against Multiple Apicomplexan Parasites.

Monique Khim, Jemma Montgomery, Mariana Laureano De Souza, Melvin Delvillar, Lyssa J Weible, Mayuri Prabakaran, Matthew A Hulverson, Tyler Eck, Rammohan Y Bheemanabonia, P Holland Alday and 5 more

Abstract read
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Monique KhimSeattle Structural Genomics Center for Infectious Disease, Seattle, Washington 98109, United States.
Jemma MontgomeryDivisions of Infectious Diseases and ResearchVA Portland Healthcare System, Portland, Oregon 97239, United States.
Mariana Laureano De SouzaDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey 07103, United States.
Melvin DelvillarDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey 07103, United States.
Lyssa J WeibleDepartment of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Reemerging Infectious DiseasesUniversity of Washington, Seattle, Washington 98109, United States.
Mayuri PrabakaranDepartment of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Reemerging Infectious DiseasesUniversity of Washington, Seattle, Washington 98109, United States.
Matthew A HulversonDepartment of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Reemerging Infectious DiseasesUniversity of Washington, Seattle, Washington 98109, United States.ORCID 0000-0002-3413-4969
Tyler EckDepartment of Chemistry and Biochemistry and Sokol Institute of Pharmaceutical Life SciencesMontclair State University, Montclair, New Jersey 07043, United States.
Rammohan Y BheemanaboniaDepartment of Chemistry and Biochemistry and Sokol Institute of Pharmaceutical Life SciencesMontclair State University, Montclair, New Jersey 07043, United States.
P Holland AldayDivisions of Infectious Diseases and ResearchVA Portland Healthcare System, Portland, Oregon 97239, United States.
David P RotellaDepartment of Chemistry and Biochemistry and Sokol Institute of Pharmaceutical Life SciencesMontclair State University, Montclair, New Jersey 07043, United States.ORCID 0000-0002-8224-218X
J Stone DoggettDivisions of Infectious Diseases and ResearchVA Portland Healthcare System, Portland, Oregon 97239, United States.ORCID 0000-0002-6098-1520
Bart L StakerSeattle Structural Genomics Center for Infectious Disease, Seattle, Washington 98109, United States.ORCID 0000-0001-9570-5086
Kayode K OjoDepartment of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Reemerging Infectious DiseasesUniversity of Washington, Seattle, Washington 98109, United States.
Purnima BhanotDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey 07103, United States.ORCID 0000-0001-5116-6973

Funding

Centers for Research on Structural Biology of Infectious Diseases: Universal Influenza Vaccine Research75N93022C00036 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI STAKER, BART · 2022 to 2025
$21.7M
Structural Analysis and Inhibitor Optimization of Cryptosporidium n-myristoyltransferase for Drug DiscoveryR01AI155536 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI STAKER, BART LEE · 2021 to 2025
$4.2M
Bumped-Kinase Inhibitor Drug Development for ToxoplasmosisR01HD102487 · NICHD · UNIVERSITY OF WASHINGTON · PI VAN VOORHIS, WESLEY C · 2021 to 2025
$3.3M
Development of dual effective kinase inhibitors as syndromic treatment of Giardiasis and CryptosporidiosisR01AI179768 · NIAID · UNIVERSITY OF WASHINGTON · PI Erkang Fan, Kayode K Ojo · 2024 to 2026
$2.3M
BLRD VA I01 BX004522NIAID NIH HHS 75N93022C00036NIAID NIH HHS R01 AI155536NIAID NIH HHS R01 AI179768NICHD NIH HHS R01 HD102487
6 · The paper itself

Abstract

Malaria, toxoplasmosis, and cryptosporidiosis are caused by apicomplexan parasites

Indexed as

Antiprotozoal AgentsCryptosporidium parvumImidazolesPlasmodium falciparumToxoplasmaCyclic GMP-Dependent Protein KinasesHumansProtozoan ProteinsAntiprotozoal AgentsCyclic GMP-Dependent Protein KinasesImidazolesProtozoan ProteinsapicomplexadrugskinasePlasmodiumToxoplasma

Identifiers

PMID40339062
PMCPMC12333026

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.