Evidence map›Paper›PMID 40339009›Full record

ArticleScience (New York, N.Y.)2025

Imaging-guided deep tissue in vivo sound printing.

Elham Davoodi, Jiahong Li, Xiaotian Ma, Alireza Hasani Najafabadi, Jounghyun Yoo, Gengxi Lu, Ehsan Shirzaei Sani, Sunho Lee, Hossein Montazerian, Gwangmook Kim and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Tissue-bioelectronics interfaces.Chemical Society reviews · 2026
    Review
  8. Prospects of Four-Dimensional Printing of Polymers for Biomedical Engineering.Polymer science & technology (Washington, D.C.) · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Mechanomedicine.Nature reviews bioengineering · 2026
    Article
  13. Review
  14. Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  15. Review
  16. Article
  17. Review
  18. Stimuli-triggered formation ofCell biomaterials · 2026
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Elham DavoodiAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0001-8578-9431
Jiahong LiAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0001-7938-9589
Xiaotian MaAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.ORCID 0009-0000-8357-9916
Alireza Hasani NajafabadiTerasaki Institute for Biomedical Innovation, Los Angeles, CA, USA.ORCID 0000-0002-8215-4374
Jounghyun YooAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0003-4253-2382
Gengxi LuAlfred E. Mann Department of Biomedical Engineering, University of Southern CA, Los Angeles, CA, USA.ORCID 0000-0001-7497-050X
Ehsan Shirzaei SaniAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0002-4609-1505
Sunho LeeAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.ORCID 0009-0008-9871-7929
Hossein MontazerianTerasaki Institute for Biomedical Innovation, Los Angeles, CA, USA.ORCID 0000-0001-6972-2667
Gwangmook KimAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0002-7469-408X
Jason WilliamsDepartment of Chemistry and Biochemistry, University of CA, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-0381-5822
Jee Won YangDivision of Chemistry and Chemical Engineering, CA Institute of Technology, Pasadena, CA, USA.ORCID 0000-0002-3257-1823
Yushun ZengAlfred E. Mann Department of Biomedical Engineering, University of Southern CA, Los Angeles, CA, USA.ORCID 0000-0001-5995-4085
Lei S LiAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0001-6164-2646
Zhiyang JinAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0002-4411-6991
Behnam SadriAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0002-1510-2646
Shervin S NiaDepartment of Chemistry and Biochemistry, University of CA, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-2538-0340
Lihong V WangAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0001-9783-4383
Tzung K HsiaiDepartment of Bioengineering, University of CA, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-1734-0792
Paul S WeissDepartment of Bioengineering, University of CA, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-5527-6248
Qifa ZhouAlfred E. Mann Department of Biomedical Engineering, University of Southern CA, Los Angeles, CA, USA.ORCID 0000-0003-1527-3020
Ali KhademhosseiniTerasaki Institute for Biomedical Innovation, Los Angeles, CA, USA.ORCID 0000-0002-2692-1524
Di WuDivision of Chemistry and Chemical Engineering, CA Institute of Technology, Pasadena, CA, USA.ORCID 0000-0002-6848-668X
Mikhail G ShapiroAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0002-0291-4215
Wei GaoAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0002-8503-4562

Funding

Research Training in Cell and Molecular BiologyT32GM145388 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jorge Torres · 2022 to 2026
$5.2M
Intravascular Deployment of a Wirelessly Powered Micro-PacerR01HL149808 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Tzung K Hsiai · 2020 to 2026
$2.8M
Laser-Engraved Wearable Sweat Sensors to Detect and Monitor Cardiometabolic DiseaseR01HL155815 · NHLBI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GAO, WEI · 2021 to 2025
$2.0M
Caltech/UCLA Individualized Theranostic Engineering to Advance Metabolic System (iTEAM)T32EB027629 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Dino Di Carlo, Azita Emami · 2020 to 2026
$2.0M
Develop a wireless, skin-conformable and dual-sensing wearable system in support of voice and upper airway telehealth careR01DC021461 · NIDCD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Wei Gao, Jianyu Li · 2024 to 2026
$1.8M
Multiphoton Microscope for Deep Tissue ImagingS10OD025017 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BENTOLILA, LAURENT A. · 2018 to 2018
$599k
Direct Detection Device for atomic resolution cryoEM of macromolecular complexesS10OD018111 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHOU, Z HONG · 2014 to 2014
$598k
NHLBI NIH HHS R01 HL149808NHLBI NIH HHS R01 HL155815NIBIB NIH HHS T32 EB027629NIDCD NIH HHS R01 DC021461NIGMS NIH HHS T32 GM145388NIH HHS S10 OD018111NIH HHS S10 OD025017
6 · The paper itself

Abstract

Three-dimensional printing offers promise for patient-specific implants and therapies but is often limited by the need for invasive surgical procedures. To address this, we developed an imaging-guided deep tissue in vivo sound printing (DISP) platform. By incorporating cross-linking agent-loaded low-temperature-sensitive liposomes into bioinks, DISP enables precise, rapid, on-demand cross-linking of diverse functional biomaterials using focused ultrasound. Gas vesicle-based ultrasound imaging provides real-time monitoring and allows for customized pattern creation in live animals. We validated DISP by successfully printing near diseased areas in the mouse bladder and deep within rabbit leg muscles in vivo, demonstrating its potential for localized drug delivery and tissue replacement. DISP's ability to print conductive, drug-loaded, cell-laden, and bioadhesive biomaterials demonstrates its versatility for diverse biomedical applications.

Indexed as

BioprintingPrinting, Three-DimensionalAnimalsBiocompatible MaterialsCross-Linking ReagentsDrug Delivery SystemsLiposomesMiceMuscle, SkeletalRabbitsUltrasonographyUrinary BladderBiocompatible MaterialsCross-Linking ReagentsLiposomes

Identifiers

PMID40339009
PMCPMC12168142

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.