Evidence map›Paper›PMID 40338972›Full record

ArticlePLoS neglected tropical diseases2025

Detection of Haemophilus ducreyi from environmental and animal samples in Cameroon.

Philippe Ndzomo, Serges Tchatchouang, Onana Boyomo, Tania Crucitti, Michael Marks, Sara Eyangoh

Abstract read
In one paragraph

Article in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Philippe NdzomoScientific Direction, Centre Pasteur du Cameroun, Yaounde, Cameroon.
Serges TchatchouangScientific Direction, Centre Pasteur du Cameroun, Yaounde, Cameroon.
Onana BoyomoDepartment of Microbiology, Faculty of Science, University of Yaounde 1, Yaounde, Cameroon.
Tania CrucittiExperimental Bacteriology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Michael MarksClinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Sara EyangohScientific Direction, Centre Pasteur du Cameroun, Yaounde, Cameroon.ORCID 0000-0002-0557-3815

Funding

European and Developing Countries Clinical Trial Partnership (EDCTP)
6 · The paper itself

Abstract

backgroundChildren in parts of Africa, the South Pacific, and Southeast Asia frequently develop cutaneous ulcers caused by two bacteria: Haemophilus ducreyi (HD) and Treponema pallidum subspecies pertenue (causative agent of yaws). The World Health Organization (WHO) aims to eradicate yaws using mass administration of azithromycin. This also leads to a temporary decrease in ulcers caused by HD followed by a rebound suggesting an ongoing reservoir of infection. The aim of this study was to investigate whether HD could spread through the environment or animals.

methodsAlongside detection of human cases of cutaneous ulcers from villages in Cameroon, we additionally collected samples from animals (dogs, cats, flies), fomites (bedsheets, clothing, benches, doors), and water sources (marigots and lakes). DNA was extracted and tested for HD and T. pallidum using two specific qPCR assays.

resultsHD was not detected in any of the environmental samples but it was on both clothing (13.3%) and in flies (27%). Flies also tested positive for T. pallidum, but at a lower rate (2.6%).

conclusionsThese results suggest that flies and some fomites may contribute to the transmission of HD. Future research should focus on determining whether either of these are capable of carrying live bacteria that can cause onward transmission.

Indexed as

ChancroidEnvironmental MicrobiologyHaemophilus ducreyiAnimalsCameroonCatsChildDipteraDogsFomitesHumansTreponema pallidumYaws

Identifiers

PMID40338972
PMCPMC12133173

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.