ArticleJournal of acquired immune deficiency syndromes (1999)2025
Randomized Clinical Trial of High Intensity Exercise in People with HIV: Effects on Muscle Composition and Inflammation.
Article in Journal of acquired immune deficiency syndromes (1999), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02101060 (Effect of Exercise Training on Inflammation and Function in HIV Infected Veterans), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Exercise Training on Inflammation and Function in HIV Infected Veterans
Who cites it
1 citing paper in PubMed.
- Effects of High-Intensity Functional Exercise on Cardiorespiratory Fitness and Physical Function in Older Adults With HIV: A Telerehabilitation Randomized Trial.Open forum infectious diseases · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundMyosteatosis affects muscle strength and mobility function, and further is associated with inflammation, yet there is limited work examining the effects of exercise training in people with HIV (PWH).
methodsWe conducted a randomized trial of 16-weeks aerobic exercise and resistance training (AEX+RT) compared to standard of care control in PWH ≥50 years of age. Muscle area, intramuscular adipose tissue (IMAT), and muscle density (Hounsfield units) of the mid-thigh was determined by computed tomography. Inflammatory markers included IL-6, hsCRP, TNF-α, and IL-18.
resultsAmong participants randomized to AEX+RT (N=17) or control (N=16), the mean (SD) age was 60.1(6.7) years, and the majority identified as black (70%) and men (91%). Significant between-group differences were found for muscle area (+7.5% vs. -3.1%, p<0.01), muscle density (+5.2% vs. -0.3%, p<0.01), and leg strength (+51.8% vs. +1.3%, (p<0.001). The decrease in IMAT after AEX+RT did not reach significance (-6.7%, p=0.07). There was no change in body weight or abdominal adiposity. At baseline, muscle density significantly correlated inversely with TNF-α and IL-6. There was a significant correlation between IMAT and inflammatory markers except IL-18. There were no significant between-group differences in changes in inflammatory markers. Percent change in inflammatory measures did not correlate with change in muscle measures.
conclusionCombined AEX+RT increased thigh muscle density, size, and strength in older PWH. Baseline association of muscle density and IMAT with inflammation underscores the need for further work in larger, more diverse populations to target underlying mechanisms for improvements in muscle quality in PWH.
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