Evidence map›Paper›PMID 40338760›Full record

ArticleJACC. Advances2025

Association Between Life's Essential 8 and Cardiovascular, Cancer, and Other Cause Mortality: The REGARDS Study.

Katherine M Huether, Laura C Pinheiro, Suzanne E Judd, D Leann Long, Monika M Safford, Donald M Lloyd-Jones, Timothy B Plante

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Research Priorities and Future Directions in Cardio-Oncology.Current treatment options in oncology · 2026
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katherine M HuetherDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA.
Laura C PinheiroDivision of General Internal Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
Suzanne E JuddDepartment of Biostatistics, School of Public Health at the University of Alabama at Birmingham, Birmingham, Alabama, USA.
D Leann LongDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Monika M SaffordDivision of General Internal Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
Donald M Lloyd-JonesFramingham Center for Population and Prevention Science and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Timothy B PlanteDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA. Electronic address: timothy.plante@uvm.edu.

Funding

Built environments on stroke risk and stroke disparities in a national sampleR01NS092706 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLABIANCHI, NATALIE, JUDD, SUZANNE E · 2016 to 2019
$2.5M
NINDS NIH HHS R01 NS092706
6 · The paper itself

Abstract

backgroundCardiovascular disease (CVD) and cancer are leading causes of death in adults. Life's Essential 8 (LE8) estimates cardiovascular health (CVH) and includes body mass index, blood pressure, blood sugar, cholesterol, diet, physical activity, sleep, and smoking. CVD, cancer, and other mortality are competing risks.

objectivesThe purpose of this study was to determine the risk of CVD mortality, cancer mortality, and other mortality by LE8-quantified CVH in a competing risk framework.

methodsREGARDS (REasons for Geographic and Racial Differences in Stroke) study recruited 30,239 Black and White adults from the 48 contiguous U.S. states from 2003 to 2007. We excluded prevalent CVD or cancer, missing LE8, or no follow-up. LE8 scores were categorized as low (<50), moderate (50-79), or high CVH (≥80). Adjusted cause-specific hazard models estimated relative hazard of CVD mortality, cancer mortality, and non-CVD, noncancer mortality as competing risks.

resultsAmong 11,385 included participants (mean age 65 ± 9 years, 52% female, 44% Black adults), 24%, 66%, and 10% had low, moderate, and high CVH, respectively. Over a median (IQR) follow-up of 14 (IQR: 8-17) years, 8% died from CVD, 7% from cancer, and 17% from other causes. Higher CVH was associated with significantly lower HRs for CVD (0.37; 95% CI: 0.28-0.49), cancer (0.48; 95% CI: 0.36-0.66), and non-CVD, noncancer (0.39; 95% CI: 0.32-0.48) mortality compared to low CVH levels.

conclusionsBetter LE8-quantified CVH was associated with lower CVD and cancer mortality in a competing risk framework. These findings underscore the significance of lifestyle modifications in mortality risk reduction, advocating for their incorporation into clinical guidelines and preventive counseling.

Indexed as

cancercardiovascular diseasecardiovascular healthLife's Essential 8mortality

Identifiers

PMID40338760
PMCPMC12277625

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.