Evidence map›Paper›PMID 40338521›Full record

ArticleDatabase : the journal of biological databases and curation2025

CancerPPD2: an updated repository of anticancer peptides and proteins.

Milind Chauhan, Amisha Gupta, Ritu Tomer, Gajendra P S Raghava

Abstract read
In one paragraph

Article in Database : the journal of biological databases and curation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  3. Review
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  5. Article
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  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Milind ChauhanDepartment of Computational Biology, Indraprastha Institute of Information Technology, Okhla Phase 3, New Delhi 110020, India.
Amisha GuptaDepartment of Computational Biology, Indraprastha Institute of Information Technology, Okhla Phase 3, New Delhi 110020, India.
Ritu TomerDepartment of Computational Biology, Indraprastha Institute of Information Technology, Okhla Phase 3, New Delhi 110020, India.ORCID 0000-0002-6171-8660
Gajendra P S RaghavaDepartment of Computational Biology, Indraprastha Institute of Information Technology, Okhla Phase 3, New Delhi 110020, India.ORCID 0000-0002-8902-2876

Funding

All India Council for Technical Education (AICTE), Department of Science and TechnologydbtIndraprastha Institute of Information TechnologyINSPIRE
6 · The paper itself

Abstract

CancerPPD2 (http://webs.iiitd.edu.in/raghava/cancerppd2/) is an updated version of CancerPPD, developed to maintain comprehensive information about anticancer peptides and proteins. It contains 6521 entries, each entry provides detailed information about an anticancer peptide/protein that include origin of the peptide, cancer cell line, type of cancer, peptide sequence, and structure. These anticancer peptides have been tested against 392 types of cancer cell lines and 28 types of cancer-associated tissues. In addition to natural anticancer peptides, CancerPPD2 contains 781 entries for chemically modified and 3018 entries for N-/C- terminus modified anticancer peptides. Few entries are also linked with 47 clinical studies and have provided the cross reference to Uniprot, DrugBank, and ThPDB2. The possible entries also linked with clinical trials. On average, CancerPPD2 contains around 85% more information than its previous version, CancerPPD. The structures of these anticancer peptides and proteins were either obtained from the Protein Data Bank (PDB) or predicted using PEPstrMOD, I-TASSER, and AlphaFold. A wide range of tools have been integrated into CancerPPD2 for data retrieval and similarity searches. Additionally, we integrated a REST API into this repository to facilitate automatic data retrieval via program. Database URL: https://webs.iiitd.edu.in/raghava/cancerppd2/api/rest.html.

Indexed as

Antineoplastic AgentsDatabases, ProteinNeoplasmsPeptidesCell Line, TumorHumansAntineoplastic AgentsPeptides

Identifiers

PMID40338521
PMCPMC12060709

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.