Evidence map›Paper›PMID 40338505›Full record

ArticleInternational urology and nephrology2025

The effect of in vitro use of FSH on sperm parameters, DNA integrity, and mitochondrial membrane potential in asthenozoospermic men.

Faezeh Etebari, Mohammad Ebrahim Rezvani, Sahar Khosravi, Mahin Izadi, Esmat Mangoli

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Article in International urology and nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Faezeh EtebariDepartment of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammad Ebrahim RezvaniDepartment of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Sahar KhosraviResearch and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mahin IzadiResearch and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Esmat MangoliResearch and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. es.mangoli@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sperm motility is a key indicator of male fertility. Decreased motility, or asthenozoospermia, highlights the need for understanding male fertility challenges. This study was designed to evaluate the effects of in vitro use of follicle-stimulating hormone (FSH) on various sperm parameters, sperm DNA integrity, and mitochondrial membrane potential. Semen samples were obtained from 20 asthenozoospermic men. Each sample was divided into control and case groups. In the case group, samples were incubated with FSH at 30 mIU/mL for 1 h, while in the control group, the samples were incubated for 1 h without treatment. Sperm parameters, DNA fragmentation, and mitochondrial membrane potential were assessed in the two groups based on WHO 2021 criteria. Progressive motility and rapid progressive motility were higher in the case group compared to the control. However, FSH did not have a significant effect on morphology, viability, DNA fragmentation, or mitochondrial membrane potential in either group. In conclusion, FSH effectively enhanced sperm motility without compromising sperm DNA integrity or mitochondrial membrane potential (MMP). Therefore, FSH can be recommended as a safe and effective option for sperm selection in patients with asthenozoospermia.

Indexed as

AsthenozoospermiaDNA FragmentationFollicle Stimulating HormoneMembrane Potential, MitochondrialSpermatozoaSperm MotilityAdultHumansIn Vitro TechniquesMaleFollicle Stimulating HormoneAsthenozoospermiaDNA integrityFSHSperm motility

Identifiers

PMID40338505

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.