Evidence map›Paper›PMID 40338502›Full record

ArticleJournal of cardiovascular translational research2025

Plasma Small Extracellular Vesicles of Ischemic Cardiomyopathy Aggravate Ventricular Remodeling Post-Myocardial Infarction and Promote miR-223-3p-mediated Dysfunction in Regulatory T Cells.

Bifang Mai, Wenlong Jiang, Jing Yang, Yuyang Chen, Zhen Qin, Yuan Li, Wenqing Tu, Yuhan Lin, Wai Seng Chan, Jianhua Wu and 3 more

Abstract read
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In one paragraph

Article in Journal of cardiovascular translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bifang Mai *Department of Cardiology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510120, China.
Wenlong Jiang *Department of Cardiovascular Institution, Shenzhen Yantian District People's Hospital, Shenzhen, 518081, China.
Jing Yang *Department of Cardiology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510120, China.
Yuyang Chen *Department of Cardiology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510120, China.
Zhen QinDepartment of Immunology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China.
Yuan LiDepartment of Cardiology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510120, China.
Wenqing TuDepartment of Cardiology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510120, China.
Yuhan LinDepartment of Cardiology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510120, China.
Wai Seng ChanDepartment of Cardiology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510120, China.
Jianhua WuDepartment of Cardiology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510120, China.
Fangzhou ChengDepartment of Cardiovascular Institution, Shenzhen Yantian District People's Hospital, Shenzhen, 518081, China. Chengfangzhou001@163.com.
Tao XuDepartment of Immunology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China. xutao25@mail.sysu.edu.cn.
Shuanglun XieDepartment of Cardiology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510120, China. xieshlun@mail.sysu.edu.cn.ORCID 0000-0003-2985-9946

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2021A1515220008National Natural Science Foundation of China 82070412Science, Technology and Innovation Commission of Shenzhen Municipality JCYJ20230807141202004
6 · The paper itself

Abstract

Treg dysfunction in ischemic cardiomyopathy (ICM) remains mechanistically unclear. We investigated ICM plasma small extracellular vesicles (ICM-sEVs) in Treg regulation and post-MI remodeling. Flow cytometry assessed Treg frequency. ICM-sEV miRNA sequencing revealed miR-223-3p enrichment, validated using miR-223

Indexed as

CardiomyopathiesExtracellular VesiclesMicroRNAsMyocardial InfarctionT-Lymphocytes, RegulatoryVentricular Function, LeftVentricular RemodelingAnimalsCase-Control StudiesCells, CulturedDisease Models, AnimalFemaleForkhead Transcription FactorsHumansMaleMiceForkhead Transcription FactorsFOXP3 protein, humanFoxp3 protein, mouseMicroRNAsMIR223, humanMIRN223 microRNA, mouseExtracellular vesiclesIschemic cardiomyopathymiR-223-3pMyocardial infarctionRegulatory T cells

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.