ArticleMolecular neurobiology2025
SCD1-Mediated Lipid Metabolism Alleviates Neuronal Ferroptosis in Subarachnoid Hemorrhage: Role of Oleic Acid Supplementation.
Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Emulsifiers in poultry nutrition-molecular mechanism of lipid metabolism and energy utilization: A meta-analysis and KEGG mapping.Poultry science · 2026Pooled it
- Compositional recalibrations of cardiolipin integrate loss of stearoyl-CoA desaturase 1 activity with mitochondrial decay in lipid-laden pancreatic β-cells.Cell communication and signaling : CCS · 2026Article
- The Mechanism of Ferroptosis and Blood-Brain Barrier Damage in Cerebrovascular Diseases.Biomedicines · 2026Review
- Elucidating the therapeutic mechanisms of quercetin in hepatic fibrosis: an integrated metabolomic and transcriptomic analysis.Frontiers in nutrition · 2026Article
- Advances in ferroptosis mechanisms and therapeutic potential in head and neck squamous cell carcinoma.Frontiers in cell and developmental biology · 2026Review
- Palmitic and oleic acids induce macrophage foam cell formation through C/EBPβ activation.Frontiers in immunology · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Subarachnoid hemorrhage (SAH) can cause severe neuronal damage and trigger multiple molecular mechanisms of cell death, among which ferroptosis has garnered significant attention due to its dependence on lipid peroxidation. In this study, ferroptosis-related markers were found to be significantly dysregulated in an in vitro SAH model, confirming the neuronal ferroptosis after SAH. Transcriptomic sequencing results indicated a marked downregulation of stearoyl-CoA desaturase 1 (SCD1), which was further validated by Western blot. Immunofluorescence demonstrated its colocalization with the neuronal marker NeuN. Overexpression of SCD1 effectively reduced ferroptosis-related markers and mitigated intracellular lipid accumulation. Additionally, supplementation with oleic acid (OA) which was the main product of SCD1, significantly alleviated hemoglobin (Hb)-induced ferroptosis. Furthermore, the ratio of saturated fatty acids (stearic acid, SA) to unsaturated fatty acids (OA) had a significant impact on neuronal survival. When the proportion of OA was increased (SA:OA = 1:2), ferroptosis was markedly inhibited. In conclusion, this study revealed the role and mechanism by which SCD1 affected neuronal ferroptosis by regulating oleic acid metabolism after SAH, providing a new potential target for mitigating neural injury after SAH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.