Evidence map›Paper›PMID 40338442›Full record

ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2025

HucMSCs-Derived Extracellular Vesicles Deliver RPS27A Protein to Manipulate the MDM2-P53 Axis and Ameliorate Neurological Dysfunction in Parkinson's Disease.

Jinyu Xu, Hongbing Lei, Chunhui Yang, Yiqing Qiu, Xi Wu

Abstract read
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In one paragraph

Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jinyu Xu *Department of Neurosurgery, Changhai Hospital, The First Affiliated Hospital of Naval Medical University, No.168, Changhai Road, Yangpu District, Shanghai, 200433, P.R. China.
Hongbing Lei *Department of Neurosurgery, Shanghai Mental Health Center, Shanghai, 201108, P.R. China.
Chunhui YangDepartment of Neurosurgery, Changhai Hospital, The First Affiliated Hospital of Naval Medical University, No.168, Changhai Road, Yangpu District, Shanghai, 200433, P.R. China.
Yiqing QiuDepartment of Neurosurgery, Changhai Hospital, The First Affiliated Hospital of Naval Medical University, No.168, Changhai Road, Yangpu District, Shanghai, 200433, P.R. China.
Xi WuDepartment of Neurosurgery, Changhai Hospital, The First Affiliated Hospital of Naval Medical University, No.168, Changhai Road, Yangpu District, Shanghai, 200433, P.R. China. wuxi_smmu@sina.com.

Funding

Changhai Hospital 234 "Climbing the Peak" Plan 2019YXK049Shanghai Natural Science Foundation General Project 21ZR1479400
6 · The paper itself

Abstract

Extracellular vesicles released from mesenchymal stem cells (MSCs-EV) have shown anti-inflammatory effects in Parkinson's disease (PD). This study was designed to assess the neuroprotective effects of human umbilical cord MSCs (hucMSCs) and the possible mechanisms involved. SH-SY5Y cells were induced with MPP

Indexed as

Extracellular VesiclesMesenchymal Stem CellsProto-Oncogene Proteins c-mdm2Ribosomal ProteinsTumor Suppressor Protein p53AnimalsCell Line, TumorHumansMaleMiceMice, Inbred C57BLParkinson DiseaseSignal TransductionUmbilical CordMDM2 protein, humanMdm2 protein, mouseProto-Oncogene Proteins c-mdm2Ribosomal ProteinsTrp53 protein, mouseTumor Suppressor Protein p53Extracellular vesiclesHuman umbilical cord mesenchymal stem cellsMDM2-P53 axisParkinson’s diseaseRPS27A

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.