Evidence map›Paper›PMID 40338353›Full record

ReviewMolecular biology reports2025

LncRNAs as behind-the-scenes molecules in cancer progression through regulating tumor-associated innate immune system cells.

Mohammad Reza Moghaddasnejad, Ali Keshavarz, Amirhossein Mardi, Negar Sadat Sherafat, Leili Aghebati-Maleki, Mohammad Hossein Mohammadi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohammad Reza MoghaddasnejadStudent Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Ali KeshavarzDepartment of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, P.O.Box: 15468-15514, Tehran, Iran.
Amirhossein MardiImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Negar Sadat SherafatStudent Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Leili Aghebati-MalekiImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. leili_aghebati_maleki@yahoo.com.
Mohammad Hossein MohammadiDepartment of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, P.O.Box: 15468-15514, Tehran, Iran. Drmohammadi@sbmu.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) have emerged as critical regulators in cancer biology, particularly in the modulation of innate immune cells within the tumor microenvironment. These lncRNAs significantly influence the phenotype and function of immune cells, such as tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), dendritic cells (DCs), natural killer cells (NK), neutrophils, and γδT cells. Thus, lncRNAs emerge as pivotal molecules in cancer development due to their capacity to modulate the innate immune system. Understanding the intricate mechanisms by which lncRNAs influence tumor-associated immune cells can pave the way for novel therapeutic strategies to restore effective anti-tumor immunity. This review highlights the diverse roles of lncRNAs in regulating the differentiation, activation, and effector functions of innate immune cells within the complex tumor microenvironment.

Indexed as

Immunity, InnateNeoplasmsRNA, Long NoncodingAnimalsDendritic CellsDisease ProgressionGene Expression Regulation, NeoplasticHumansKiller Cells, NaturalMacrophagesMyeloid-Derived Suppressor CellsNeutrophilsTumor-Associated MacrophagesTumor MicroenvironmentRNA, Long NoncodingInnate immune cellsLncRNAmiRNAsTumor microenvironment

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.