Evidence map›Paper›PMID 40338344›Full record

ArticleActa diabetologica2025

Relationship between complement and macrophage markers with kidney survival in patients with diabetic nephropathy.

Ozcan Uzun, Cihan Heybeli, Fatma Sema Anar Kutlu, Manolya Celebioglu Pekiner, Filiz Yıldırım, Caner Cavdar, Sulen Sarioglu

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In one paragraph

Article in Acta diabetologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ozcan UzunYalova Research and Training Hospital, Yalova, Turkey.
Cihan HeybeliDivision of Nephrology, Dokuz Eylül University School of Medicine, Izmir, Turkey. cihan.heybeli@deu.edu.tr.ORCID http://orcid.org/0000-0001-7903-1106
Fatma Sema Anar KutluDepartment of Pathology, Dokuz Eylül University School of Medicine, Izmir, Turkey.
Manolya Celebioglu PekinerDivision of Nephrology, Ege University School of Medicine, Izmir, Turkey.
Filiz YıldırımZonguldak Atatürk State Hospital, Zonguldak, Turkey.
Caner CavdarDivision of Nephrology, Dokuz Eylül University School of Medicine, Izmir, Turkey.
Sulen SariogluDepartment of Pathology, Dokuz Eylül University School of Medicine, Izmir, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetic nephropathy (DN) is the leading cause of end-stage kidney disease (ESKD) worldwide. Macrophages and the complement system have interrelated roles in DN. We aimed to determine associations between macrophage and complement markers with the progression of DN.

methodsThis retrospective cohort study included patients diagnosed with sole DN by kidney biopsy. Using immunohistochemistry, CD68

resultsForty-six patients were included. The median SCr at baseline was 2.7 (1.41-3.1) mg/dL. During the median follow-up of 32 months (range 6-54), 50% of patients reached the primary outcome. Most of the clinical and histological findings were comparable between progressors and non-progressors, while progressors had a higher median number of glomerular CD68+ cells and a higher percentage of glomerulosclerosis. After adjustments for age, sex, and SCr, the median glomerular CD68+ cell number was the sole independent predictor of progression. Glomerular C4d was associated with nephrotic-range proteinuria but not with the progression of kidney failure.

conclusionsGlomerular CD68+ cell count may serve as a promising predictor of kidney disease progression among patients with DN. Glomerular C4d was associated with nephrotic-range proteinuria but not with the progression of kidney failure.

Indexed as

Diabetic NephropathiesKidneyMacrophagesAdultAgedAntigens, CDAntigens, Differentiation, MyelomonocyticBiomarkersCD68 MoleculeComplement C4bDisease ProgressionFemaleHumansKidney Failure, ChronicKidney GlomerulusMaleAntigens, CDAntigens, Differentiation, MyelomonocyticBiomarkersCD68 antigen, humanCD68 MoleculeComplement C4bReceptors, Cell SurfaceComplement system proteinsDiabetes mellitusEnd-stage kidney disease progressionMacrophagesRenal failure

Identifiers

PMID40338344
PMCPMC12578723

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.