Evidence map›Paper›PMID 40338340›Full record

ArticleJournal of molecular histology2025

Autografted hair follicles with dermal papilla removed promote wound repair and regeneration in Bama mini-pigs.

Wenzi Liang, Chang Mai, Yuandong Yuan, Xiuwen Chen, Bozhi Cai, Na Ni, Chutong Zhuang, Changmin Lin, Keng Huang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wenzi Liang *Department of Histology and Embryology, Shantou University Medical College, Shantou, 515041, Guangdong Province, People's Republic of China.
Chang Mai *Hepatological Surgery Department, Huizhou Third People's Hospital, Huizhou, People's Republic of China.
Yuandong YuanPhysical Examination Center, Second Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong Province, People's Republic of China.
Xiuwen ChenMolecular Cardiology Laboratory, First Affiliated Hospital of Shantou University Medical College, Shantou, People's Republic of China.
Bozhi CaiMolecular Cardiology Laboratory, First Affiliated Hospital of Shantou University Medical College, Shantou, People's Republic of China.
Na NiDepartment of Histology and Embryology, Shantou University Medical College, Shantou, 515041, Guangdong Province, People's Republic of China.
Chutong ZhuangPhysical Examination Center, Second Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong Province, People's Republic of China.
Changmin LinDepartment of Histology and Embryology, Shantou University Medical College, Shantou, 515041, Guangdong Province, People's Republic of China. cocolin@stu.edu.cn.
Keng HuangPhysical Examination Center, Second Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong Province, People's Republic of China. huangkeng789@foxmail.com.

Funding

National Natural Science Foundations of China 81972957National Natural Science Foundations of China 82472574
6 · The paper itself

Abstract

Autologous free flap transplantation is the most economical and effective method for clinical treatment of large-area trauma, but the shortage of flap donors prevents widespread use of this method. Hair follicle stem cells have great potential to repair wounds, but wound repair by hair follicle stem cells has not yet met expectations. We used a wound model of Bama mini-pigs and treated the wound with autologous hair follicles or flaps. The wound healing was observed on days 7, 14, and 21 post-surgery and wound healing rates were analyzed using Image J software. Hematoxylin and eosin staining was performed to evaluate re-epithelialization of the wound. Immunofluorescence staining was used to detect the expression of hair follicle stem cell markers (CK15, Sox9) and explore the mechanism of wound repair. This research found that autologous hair follicles can accelerate wound healing. The efficiency of hair follicles in wound repair is related to their structure. Dermal papilla acts as a biological barrier to hair follicle-mediated wound repair. Dermal papilla removal enhances wound healing efficiency, likely by relieving dermal papilla-imposed restrictions on hair follicle stem cell migration. Autologous hair follicles for wound repair has the advantages of minimal damage, simple fabrication, and abundant source, which may be able to replace the flap transplantation as a therapeutic strategy in the future. This study is helpful to elucidate the regulatory mechanism of hair follicles involved in wound repair, and has important academic and clinical value for solving the problem of shortage flap donor.

Indexed as

DermisHair FollicleRegenerationWound HealingAnimalsRe-EpithelializationStem CellsSwineSwine, MiniatureTransplantation, AutologousBama mini-pigsDermal papillaHair follicle stem cellsTransplantationWound repair

Identifiers

PMID40338340

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.