Evidence map›Paper›PMID 40338289›Full record

ArticleHead and neck pathology2025

Osteosarcoma Arising in Noonan Syndrome/RASopathy Complex: First Case Report.

Najwa Yousef, John Basile, Michael E Kallen, John F Caccamese, Donita Dyalram, Joshua Lubek, Farnaz Valaei, Jeffery Price, Layne N Raborn, Michael T Collins and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Najwa YousefDepartment of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, MD, USA.
John BasileDepartment of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, MD, USA.
Michael E KallenDepartment of Anatomic Pathology, University of Maryland School of Medicine, Baltimore, MD, USA.
John F CaccameseUniversity of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Donita DyalramUniversity of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Joshua LubekUniversity of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Farnaz ValaeiDepartment of Oral-Maxillofacial Surgery, School of Dentistry, University of Maryland Baltimore, Baltimore, MD, USA.
Jeffery PriceDepartment of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, MD, USA.
Layne N RabornSkeletal Disorders and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Michael T CollinsSkeletal Disorders and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Ahmed S SultanDepartment of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, MD, USA. asultan1@umaryland.edu.ORCID http://orcid.org/0000-0001-5286-4562

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNoonan syndrome (NS) is a developmental malformation condition in the RASopathies group, characterized by variable clinical and molecular features. The syndrome is genetically heterogeneous, with the most frequent mutation found in approximately 50% of cases occurring in the PTPN11 gene. NS is reported to be associated with neurogenic, hematopoietic, melanocytic and other visceral malignancies, but osteosarcoma development has not been reported in association with NS. CASE REPORT: Therefore, we report the first case of a male with NS who developed osteosarcoma of the mandible in a background of long-standing polyostotic fibrous dysplasia (FD) of the craniofacial bones.

Indexed as

Fibrous Dysplasia, PolyostoticMandibular NeoplasmsNoonan SyndromeOsteosarcomaHumansMaleFibrous dysplasiaNoonan syndromeOsteosarcomaPTPN11 mutationRASopathy

Identifiers

PMID40338289
PMCPMC12061803

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