Evidence map›Paper›PMID 40338234›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Anti-TNFα and Anti-IL-1β Monoclonal Antibodies Preserve BV-2 Microglial Homeostasis Under Hypoxia by Mitigating Inflammatory Reactivity and ATF4/MAPK-Mediated Apoptosis.

Linglin Zhang, Chaoqiang Guan, Sudena Wang, Norbert Pfeiffer, Franz H Grus

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Linglin ZhangDepartment of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, 55131 Mainz, Germany.ORCID 0000-0002-1432-6082
Chaoqiang GuanDepartment of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, 55131 Mainz, Germany.ORCID 0009-0000-8524-284X
Sudena WangDepartment of Anesthesiology, University Medical Center, Johannes Gutenberg University Mainz, 55131 Mainz, Germany.ORCID 0000-0003-3549-2407
Norbert PfeifferDepartment of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, 55131 Mainz, Germany.
Franz H GrusDepartment of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The disruption of microglial homeostasis and cytokine release are critical for neuroinflammation post-injury and strongly implicated in retinal neurodegenerative diseases like glaucoma. This study examines microglial responses to chemical hypoxia induced by cobalt chloride (CoCl

Indexed as

anti-IL-1βanti-TNFαapoptosishypoxiainflammatory pathwaysmicrogliamitochondriaproteomics

Identifiers

PMID40338234
PMCPMC11939723

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.