Evidence map›Paper›PMID 40338207›Full record

ArticleACS infectious diseases2025

Discovery of 2,4,5-Substituted Benzoxazole Derivatives as Pks13 Inhibitors via the Scaffold Hopping Strategy.

Babatunde Samuel Obadawo, Priscila Cristina Bartolomeu Halicki, Kindra L Becker, Jessica C Seeliger, Kyle H Rohde, Steven J Sucheck

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Babatunde Samuel ObadawoDepartment of Chemistry and Biochemistry, University of Toledo, 2801 West Bancroft Street, Toledo, Ohio 43606, United States.
Priscila Cristina Bartolomeu HalickiBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32827, United States.ORCID 0000-0002-1643-0422
Kindra L BeckerDepartment of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States.
Jessica C SeeligerDepartment of Pharmacological Sciences, Stony Brook University, Stony Brook, New York 11794, United States.ORCID 0000-0001-7148-1073
Kyle H RohdeBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32827, United States.ORCID 0000-0001-9838-3238
Steven J SucheckDepartment of Chemistry and Biochemistry, University of Toledo, 2801 West Bancroft Street, Toledo, Ohio 43606, United States.ORCID 0000-0003-0082-3827

Funding

Synthesis of natural product scaffold selectively active against dormant Mycobacterium tuberculosisR21AI135313 · NIAID · UNIVERSITY OF TOLEDO · PI ROHDE, KYLE H, SUCHECK, STEVEN · 2018 to 2019
$423k
NIAID NIH HHS R21 AI135313
6 · The paper itself

Abstract

Pks13, an essential enzyme for

Indexed as

Antitubercular AgentsBacterial ProteinsBenzoxazolesEnzyme InhibitorsMycobacterium tuberculosisDrug DiscoveryHumansMicrobial Sensitivity TestsStructure-Activity RelationshipAntitubercular AgentsBacterial ProteinsBenzoxazolesEnzyme Inhibitorsantitubercular therapybenzoxazole derivativesMycobacterium tuberculosis (Mtb)Pks13 inhibitorsscaffold hoppingstructure−activity relationships (SAR)

Identifiers

PMID40338207
PMCPMC12977085

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.