ArticleCancer discovery2025
Trends in Cancer Incidence and Mortality Rates in Early-Onset and Older-Onset Age Groups in the United States, 2010-2019.
Article in Cancer discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The global state of GLIM criteria in oncology: a bibliometric analysis of research trends (2019-2025).Frontiers in nutrition · 2026Pooled it
- Clinical Practice Guideline: Colorectal Cancer—Diagnosis, Treatment, Prevention, and Long-Term Follow-Up Care.Deutsches Arzteblatt international · 2025Guideline
- Young Women Diagnosed With Breast Cancer: Why Is No One Telling Me to Get a Mammogram?Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2026Article
- An Interactive Narrative Intervention to Increase Adolescents' Knowledge and Self-Efficacy to Reduce Alcohol Use: Pre-Post Study.JMIR formative research · 2026Article
- EBCC-15 manifesto: Removing age-related barriers to improve equity in breast cancer care.Breast (Edinburgh, Scotland) · 2026Review
- Biological aging and generational shifts in early-onset cancer risk.Nature medicine · 2026Article
- Recent trends in Early-Onset cancer incidence rates.Journal of the National Cancer Institute · 2026Article
- Microplastics in early-onset carcinogenesis.Carcinogenesis · 2026Review
- Microbial induction of MHC-II expression in colon cancer cells overcomes immunotherapy resistance and limits metastasis.bioRxiv : the preprint server for biology · 2026Article
- Cancer trends in England in younger adults from 2001-2023: comparing incidence, mortality and stage at diagnosis.medRxiv : the preprint server for health sciences · 2026Article
- Increasing Burden of Early-Onset Cancers: Disentangling the Contributions of Changes in Risk from Demographic Shifts.Cancer research communications · 2026Article
- Towards a clinically integrated artificial intelligence tool for triage of skin cancer.NPJ digital medicine · 2026Article
- Charleson and Elixhauser Comorbidity Indices in Predicting Mortality Among Young and Old Cervical Cancer Patients.Cancer medicine · 2026Article
- Striking the right balance with type I interferon signalling in cancer.Nature reviews. Cancer · 2026Review
- Accelerating discovery of cancer causes for prevention in the era of rising early-onset cancers.Cell · 2026Review
- Heterogeneity in Survival Over Time by Age, Sex, and Subsite in Early-Onset Oral Cavity Cancer.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026Article
- Is Heavy Alcohol Use Associated With Young-Onset Pancreatic Cancer?Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026Article
- "I had to work it out for myself": opportunities for primary care to fill a void for early-onset breast cancer survivors.Journal of cancer survivorship : research and practice · 2026Article
- Exploring the link between nitrate exposure and thyroid cancer: A nationwide state-level analysis.Journal of the Endocrine Society · 2026Article
- Assessing Training Practices and Gaps for Staff Involved in the Delivery of Oncology Financial Navigation: A Qualitative Study.Current oncology (Toronto, Ont.) · 2026Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
We estimated age-standardized cancer incidence (2010-2019) and mortality rates (2010-2022) in the United States to investigate whether cancer rates have increased at younger ages. Fourteen cancers had incidence rates that increased in at least one early-onset age group (i.e., 15-29-, 30-39-, and 40-49-year-olds)-9 of these also increased in at least one older-onset age group (i.e., 50-59, 60-69, and 70-79; i.e., female breast, colorectal, kidney, testicular, uterine and pancreatic cancers, and several lymphoid neoplasms). The largest absolute increases in 2019 compared with expected diagnoses based on 2010 rates were female breast (n = 4,834 additional cancers), colorectal (n = 2,099), kidney (n = 1,793), and uterine cancers (n = 1,209). Although there were not concomitant increases in mortality rates for most cancers, colorectal, uterine, and testicular cancer mortality rates increased in early-onset age groups. The drivers of increasing incidence rates are cancer-specific and could include a combination of established and perhaps new etiologic factors, and increased detection. SIGNIFICANCE: In the United States, incidence rates of some cancers have increased in early-onset age groups. For many of these cancers, rates have also increased in older-age groups, suggesting that the impact of changes in risk factor prevalence and/or improvements in detection could affect risk across the age range. See related commentary by Cann and Eng, p. 1309.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.