Evidence map›Paper›PMID 40337868›Full record

SynthesisImmunotherapy2025

Arthralgia in patients with cancer receiving immune checkpoint inhibitors: a systematic review and meta-analysis.

Yoshito Nishimura, Jonathan Estaris, Mako Koseki, Evelyn Elias, Fnu Chesta, Kensuke Takaoka, Theresa Shao, Nobuyuki Horita, Yu Fujiwara

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Immunotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yoshito NishimuraDepartment of Medicine, Mayo Clinic, Rochester, MN, USA.
Jonathan EstarisDepartment of Medicine, John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI, USA.
Mako KosekiDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Evelyn EliasDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Fnu ChestaDepartment of Medicine, John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI, USA.
Kensuke TakaokaDepartment of Medicine, John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI, USA.
Theresa ShaoDivision of Hematology and Medical Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nobuyuki HoritaChemotherapy Center, Yokohama City University Hospital, Yokohama, Japan.
Yu FujiwaraDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough immune checkpoint inhibitors (ICIs) are widely used for patients with cancer, evidence of the impact of ICIs on the incidence of arthralgia remains limited.

objectiveTo evaluate the impact of ICIs on arthralgia incidences in patients with cancer.

methodsWe performed a systematic review to identify phase 3 randomized control trials (RCTs) evaluating ICIs in patients with cancer and reporting the incidence of arthralgia. We performed a meta-analysis to pool odds ratios (ORs) of any grade and grade 3-5 arthralgia.

resultsForty RCTs (

conclusionsThese results could guide oncologists to assess arthralgia in patients receiving ICIs.

Indexed as

ArthralgiaImmune Checkpoint InhibitorsNeoplasmsHumansIncidenceRandomized Controlled Trials as TopicImmune Checkpoint InhibitorsarthralgiaCTLA-4Immune checkpoint inhibitorsimmune-related adverse eventPD-1systematic review

Identifiers

PMID40337868
PMCPMC12091910

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.