Evidence map›Paper›PMID 40337674›Full record

ArticleIranian journal of microbiology2025

Antifungal activity of polyphenolic compounds against fluconazole-susceptible and -resistant

Harmed Fakhim, Bahar Mohamadi, Shima Gharibi, Medhi Rahimmalek, Mahnaz Hosseini Rizi, Mahsa Shelerangkon, Elahe Nasri, Fariba Dorostkar, Antoni Szumny, Afsane Vaezi

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Article in Iranian journal of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Harmed FakhimInfectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Bahar MohamadiDepartment of Microbiology, Tehran North Branch, Islamic Azad University, Tehran, Iran.
Shima GharibiInfectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Medhi RahimmalekDepartment of Horticulture, College of Agriculture, Isfahan University of Technology, Isfahan, Iran.
Mahnaz Hosseini RiziInfectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Mahsa ShelerangkonInfectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Elahe NasriInfectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Fariba DorostkarDepartment of Medical Laboratory Sciences, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran.
Antoni SzumnyDepartment of Food Chemistry and Biocatalysis, Wrocław University of Environmental and Life Sciences, Wroclaw, Poland.
Afsane VaeziDepartment of Medical Laboratory Sciences, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: The rapid emergence of resistant fungi is occurring worldwide, and this crisis has been attributed to the lack of new antifungal drug development. This issue emphasizes the need for innovation in finding novel antifungals. There is an increasing interest in using the natural products of plants with high biological activity as alternatives to synthetic drugs. This study aimed to evaluate the possible applicability of polyphenols as alternative antifungal drugs to treat resistant Materials and Methods: A panel of fluconazole-resistant (n=14) and fluconazole-susceptible (n=26) clinical Results: The MIC values of 40 Conclusion: The increasing antifungal resistance highlights the importance of evaluating new drugs that are more robust against resistance. This study suggests that tannic acid could be considered a novel antifungal agent for managing fungal infections, including multidrug-resistant non-

Indexed as

Antifungal activityCandida speciesFluconazole resistancePolyphenolic compoundsTannic acid

Identifiers

PMID40337674
PMCPMC12053427

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.