ArticleOncology letters2025
Stereotactic body radiotherapy for early‑stage non‑small cell lung cancer: Comprehensive analysis of outcomes and recurrence from a single‑center experience.
Article in Oncology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to analyze prognostic factors in patients with early-stage non-small cell lung cancer (NSCLC) treated with stereotactic body radiotherapy (SBRT), focusing on symptomatic radiation pneumonitis (RP) and treatment failure patterns. This retrospective cohort study included 271 patients with early-stage NSCLC (276 lesions) treated with SBRT from May 2012 to January 2022. SBRT was administered according to standardized protocols with doses ranging from 28.5 to 80 Gy in 1 to 10 fractions. Tumor recurrence, RP, and failure patterns were assessed through imaging and clinical evaluations. Prognostic factors for overall survival (OS) and local control (LC) were identified using Kaplan-Meier survival analysis, Cox models, and logistic regression for RP risk. With a median follow-up of 30.8 months, the 1-, 2- and 3-year OS rates were 96.1, 91.8, and 86.5%, respectively, and LC rates were 98.8, 96.5, and 92.9%, respectively. The Eastern Cooperative Oncology Group performance status (P=0.002) and higher fractional dose (P=0.041) were significant predictors of OS. Larger tumor size (P<0.001) and higher solid-to-total tumor ratio (P=0.028) were associated with increased local recurrence risk. Symptomatic RP (7.2% of lesions) was associated with solid tumor size (P=0.050). Larger tumors with a higher solid component had more in-field recurrences, while marginal recurrences were often attributable to air space spread and pleural involvement. Higher fractional doses in SBRT benefit patients with early-stage NSCLC, especially those with larger tumors or significant solid components, suggesting that dose escalation or more biologically effective therapies could enhance outcomes and optimize SBRT protocols.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.