ArticleCureus2025
Multidisciplinary Management of Aggressive Orbital Rhabdomyosarcoma in an Adult Patient: A Case Report and Literature Review.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Embryonic rhabdomyosarcoma (RMS) is a common tumor in children. In adults, it is an extremely rare tumor. There are three histological subtypes: embryonic, alveolar, and pleomorphic RMS. Pleomorphic RMS is most common in adults. Orbital site is a common primary site in children. In adults, it is an unusual presentation site. Management of RMS is based on a multimodal approach, including surgery, radiotherapy, and chemotherapy. In the pediatric population, a multidisciplinary approach has been validated in prospective trials in Europe and the USA. In adults, there is no consensus on the management of these tumors in the absence of dedicated clinical trials. Management of adult RMS is based on pediatric guidelines and data from retrospective series of adults. The prognosis of RMS differs according to age. Adult RMS has worse survival than in children. We report a case of a 37-year-old female patient presenting with an orbital embryonic RMS. Treatment involved enucleation, but rapid local progression was observed. Chemotherapy was initiated, but evaluation after three cycles demonstrated significant tumor progression. Surgical intervention combined with radiotherapy was performed, followed by adjuvant chemotherapy. This case highlights the aggressive biology of embryonal RMS in adults and the role of a multimodal treatment approach.
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