ArticleCureus2025
Frank's Sign: A Clinical Predictor of Ischaemic Strokes.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Association of Diagonal Earlobe Crease (Frank's Sign) with Intracranial Aneurysm Rupture at Small Sizes.Brain sciences · 2026Article
- Diagnostic model for angiographic obstructive coronary artery disease combining CHG, DELC, and traditional risk factors: a bootstrap validation study.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frank's sign is a diagonal crease on the earlobe and has been linked to cardiovascular disease. This prospective observational study aimed to assess the association between Frank's sign and ischaemic strokes. Conducted over three months in a UK district general hospital, the study analysed data from 137 consecutive patients admitted to stroke and elderly care wards. Patient records included demographic and medical history data, and physical examinations identified the presence of Frank's sign. Statistical analysis using the chi-squared test demonstrated a significant association between ischaemic strokes and Frank's sign, even after excluding patients with pre-existing cardiovascular disease. These findings suggest Frank's sign could serve as a clinical predictor for ischaemic stroke. Recognizing this sign may help healthcare providers identify at-risk individuals and implement preventative strategies for managing stroke risk factors. Further research is needed to explore additional causes and refine its predictive value.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.