Evidence map›Paper›PMID 40337514›Full record

ArticleFrontiers in pharmacology2025

Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway.

Huangen Li, Yi Gao, Minglian Huang, Hongling Zhang, Qingqing Wu, Youpei Huang, Xiaotong Ye, Weiwen Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Huangen LiDepartment of Critical Care Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, China.
Yi GaoDepartment of General Medicine, Xiamen Changgeng Hospital Affiliated to Huaqiao University, Xiamen, China.
Minglian HuangDepartment of Critical Care Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, China.
Hongling ZhangDepartment of Critical Care Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, China.
Qingqing WuDepartment of Critical Care Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, China.
Youpei HuangDepartment of Critical Care Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, China.
Xiaotong YeSchool of Medicine, Huaqiao University, Quanzhou, China.
Weiwen ChenDepartment of Critical Care Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Tetramethylpyrazine (TMPZ), an active alkaloid derived from traditional Chinese medicine, has shown anti-inflammatory and anti-pyroptotic properties. However, its role in acute pancreatitis (AP)-induced pyroptosis remains unclear. This study aims to investigate the effects of TMPZ on AP-induced pyroptosis and its potential mechanisms. Materials and methods: A cerulein-induced AP rat model was used to evaluate TMPZ's protective effects Results: TMPZ alleviated pancreatic histopathological damage, reduced apoptosis, and decreased serum amylase levels and pro-inflammatory cytokines (IL-1β, IL-18). TMPZ also suppressed pyroptosis by inhibiting NLRP3 inflammasome activation and downregulating pyroptosis-related proteins (NLRP3,caspase-1, ASC, GSDMD) while upregulating NRF2 and HO-1 expression. NRF2 siRNA attenuated TMPZ's anti-inflammatory and pyroptosis-inhibitory effects, confirming the involvement of the NRF2 pathway. Conclusion: TMPZ mitigates AP-induced inflammation and injury by modulating pyroptosis via the NRF2 signaling pathway. These findings suggest TMPZ's therapeutic potential for AP.

Indexed as

active alkaloidanti-inflammatoryanti-pyroptoticNLRP3 inflammasomenuclear factor erythroid 2-related factor 2

Identifiers

PMID40337514
PMCPMC12055549

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