ArticlePrecision radiation oncology2024
Radiation induced liver injury (RILI) evaluation using longitudinal computed tomography (CT) in image-guided precision murine radiotherapy.
Article in Precision radiation oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Editorial: 2Precision radiation oncology · 2025Article
- A nomogram for predicting overall survival in advanced hepatocellular carcinoma patients receiving radiotherapy combined with targeted therapy: a multicenter retrospective study.Translational cancer research · 2025Article
- Neoadjuvant versus adjuvant radiotherapy for centrally located hepatocellular carcinoma: a propensity score matching study based on two prospective phase II trials.Therapeutic advances in medical oncology · 2025Article
- Radiation induced liver injury (RILI) evaluation using longitudinal computed tomography (CT) in image-guided precision murine radiotherapy.Precision radiation oncology · 2024Article
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5 authors.
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Abstract
Purpose: We aim to perform image-guided, dose-escalated, well-controlled liver-irradiated animal studies and subsequently evaluate radiation induced liver injury (RILI) using longitudinal CT. Methods: Eighteen 6-8 weeks mice were divided into three groups: control, 15Gy and 30Gy irradiated groups. The animal protocol was approved by the animal care ethics committee of our institution. Precision radiotherapy started with CT simulation, followed by treatment planning using volumetric modulated arc therapy (VMAT), image guidance with cone beam CT (CBCT) and radiation delivery on a medical linear accelerator. Weekly CT was conducted on the same CT simulator using same scanning parameters. At the end of fifth week, all mice were sacrificed, and histological staining was performed. Body weight, liver volume, HU values and histogram distributions were analyzed. Results: Body weight of irradiation groups was significantly reduced compared to that of the control group ( Conclusion: Longitudinal unenhanced CT is a useful imaging tool to evaluate the severity and progression of radiation induced liver injury.
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