ArticlePrecision radiation oncology2024
Feasibility planning study of lattice radiotherapy for palliation in bulky tumors.
Article in Precision radiation oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- VMAT-based lattice radiotherapy for advanced bulky hepatocellular carcinoma within multimodality treatment: a consecutive feasibility series.Clinical and translational radiation oncology · 2026Article
- Dosimetric comparison of pipe-joint versus conventional VMAT for lattice radiotherapy in bulky tumors: a retrospective planning study.Radiation oncology (London, England) · 2026Article
- A preclinical setup for spatially fractionated radiation therapy with electrons.Medical physics · 2026Article
- Article
- The central role of radiotherapy in remodeling the tumor immune microenvironment: mechanisms and therapeutic implications.Frontiers in cell and developmental biology · 2026Review
- Individualized VMAT lattice radiotherapy on a standard flattening-filter linear accelerator for advanced bulky tumors: a retrospective feasibility and early clinical experience.Frontiers in oncology · 2026Article
- Lattice radiotherapy for extensive liver metastases in synchronous EGFR-mutant lung adenocarcinoma and small cell lung cancer.Clinical and translational radiation oncology · 2025Article
- Article
- Novel pencil-beam scanning proton lattice radiation therapy for the treatment of bulky liver cancer: dosimetric comparison with VMAT-lattice radiotherapy.Frontiers in oncology · 2025Article
- Feasibility planning study of lattice radiotherapy for palliation in bulky tumors.Precision radiation oncology · 2024Article
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Authors and funding
6 authors.
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Abstract
Purpose: Lattice radiotherapy can potentially deliver high doses to the tumor core, while conventional doses to the periphery resulting in improved response rates in large tumors (> 5 cm). We assessed the feasibility of planning lattice radiotherapy and dosimetrically compared it with conventional radiotherapy. Methods: This retrospective dosimetric study evaluated 10 patients with large tumors (> 5 cm) treated with palliative intent with a dose of 20Gy in five fractions. High-dose lattice points were created at doses of 50Gy in non-hepatic tumors and 35Gy in hepatic tumors. Lattice plans were compared with treatment plans regarding dose coverage and organ-at-risk dosimetry. Results: Treated sites included soft tissue metastases to the neck, lungs, abdomen, pelvis, and liver. The mean lesion volume was 1103 cc (352-3173 cc). The maximum tumor size was 16 cm. The target volume coverage was > 95% in all but one case (88% to achieve organ constraints). Dosimetry and organ-at-risk doses were similar in both palliative treatment and simulated lattice plans. Conclusion: Lattice radiotherapy is feasible in large tumors using volumetric-modulated arc therapy and achieves good coverage while meeting organ constraints. However, a prospective clinical evaluation is required to confirm its efficacy.
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