Evidence map›Paper›PMID 40337456›Full record

ArticlePrecision radiation oncology2024

Mimicking large spot-scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform.

Fada Guan, Dadi Jiang, Xiaochun Wang, Ming Yang, Kiminori Iga, Yuting Li, Lawrence Bronk, Julianna Bronk, Liang Wang, Youming Guo and 5 more

Abstract read
In one paragraph

Article in Precision radiation oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Editorial: 2Precision radiation oncology · 2025
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Fada GuanDepartment of Radiation Physics The University of Texas MD Anderson Cancer Center Houston Texas USA.ORCID https://orcid.org/0000-0001-8477-7391
Dadi JiangDepartment of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas USA.
Xiaochun WangDepartment of Radiation Physics The University of Texas MD Anderson Cancer Center Houston Texas USA.
Ming YangDepartment of Radiation Physics The University of Texas MD Anderson Cancer Center Houston Texas USA.
Kiminori IgaDepartment of Radiation Physics The University of Texas MD Anderson Cancer Center Houston Texas USA.
Yuting LiDepartment of Radiation Physics The University of Texas MD Anderson Cancer Center Houston Texas USA.
Lawrence BronkDepartment of Radiation Physics The University of Texas MD Anderson Cancer Center Houston Texas USA.
Julianna BronkDepartment of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas USA.
Liang WangDepartment of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas USA.
Youming GuoDepartment of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas USA.
Narayan SahooDepartment of Radiation Physics The University of Texas MD Anderson Cancer Center Houston Texas USA.
David R GrosshansDepartment of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas USA.
Albert C KoongDepartment of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas USA.
Xiaorong R ZhuDepartment of Radiation Physics The University of Texas MD Anderson Cancer Center Houston Texas USA.
Radhe MohanDepartment of Radiation Physics The University of Texas MD Anderson Cancer Center Houston Texas USA.ORCID https://orcid.org/0000-0003-3746-4557

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

Previously, a synchrotron-based horizontal proton beamline (87.2 MeV) was successfully commissioned to deliver radiation doses in FLASH and conventional dose rate modes to small fields and volumes. In this study, we developed a strategy to increase the effective radiation field size using a custom robotic motion platform to automatically shift the positions of biological samples. The beam was first broadened with a thin tungsten scatterer and shaped by customized brass collimators for irradiating cell/organoid cultures in 96-well plates (a 7-mm-diameter circle) or for irradiating mice (1-cm

Indexed as

proton therapyrobotic motion techniqueultra‐high dose rate FLASH

Identifiers

PMID40337456
PMCPMC11934911

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.