ArticleAnnals of medicine and surgery (2012)2025
The relationship between oral burns and oral squamous cell carcinoma: a systematic review.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Micro-RNAs (miRNAs) have been found to play crucial roles in various biological processes and have been implicated in the development and progression of many diseases, including cancer. In recent years, several studies have suggested that miRNA may have a potential role in the relationship between oral burns and various. This systematic review aims to summarize the current evidence on the roles of miRNA in the relationship between oral burns and oral squamous cell carcinoma (OSCC). Materials and methods: The present systematic review was performed using PubMed, Google Scholar, Science Direct, ProQuest, Ovid, and Embase from April 2024 to May 2024 following the "Preferred Reporting Items for Systematic Reviews" guidelines. The keywords, including "oral burn OR burning tongue OR burning mouth" AND "Oral squamous cell carcinoma" AND "miRNA." Results: The study reviewed 9 publications, examining miRNA interactions common to oral burns and cancers. Among them, 5 studies focused on various burn types, while 4 addressed oral malignancies. Synthesizing these findings identified 5 shared miRNAs between burns and oral cancers. Regarding burn types, thermal burns were most mentioned, followed by carbon dioxide laser and chemical burns. For cancer, oral squamous cell carcinoma was predominant, with one study on tongue squamous cell carcinoma. Noteworthy miRNAs include hsa-miR-205, hsa-miR-18a, hsa-mir-23b, hsa-mir-203, and hsa-mir-150, each exhibiting distinct roles and expression patterns in burns and carcinogenesis. Conclusion: Overall, the findings of this systematic review highlight the potential importance of miRNA in the relationship between oral burns and OSCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.