Evidence map›Paper›PMID 40337307›Full record

ArticleRSC medicinal chemistry2025

New

Konstantina Stavropoulou, Angeliki Kaimaki, Maria Nikolaou, Ana K Brown, Andrew Tsotinis, Martin C Taylor, John M Kelly, Ioannis P Papanastasiou

Abstract read
In one paragraph

Article in RSC medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Konstantina StavropoulouDivision of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens Panepistimiopoli-Zografou 157 71 Athens Greece papanastasiou@pharm.uoa.gr.ORCID https://orcid.org/0009-0008-4828-5339
Angeliki KaimakiDivision of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens Panepistimiopoli-Zografou 157 71 Athens Greece papanastasiou@pharm.uoa.gr.
Maria NikolaouDivision of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens Panepistimiopoli-Zografou 157 71 Athens Greece papanastasiou@pharm.uoa.gr.
Ana K BrownDivision of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens Panepistimiopoli-Zografou 157 71 Athens Greece papanastasiou@pharm.uoa.gr.ORCID https://orcid.org/0000-0001-5127-0316
Andrew TsotinisDivision of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens Panepistimiopoli-Zografou 157 71 Athens Greece papanastasiou@pharm.uoa.gr.ORCID https://orcid.org/0000-0002-4334-4810
Martin C TaylorDepartment of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine Keppel Street London WC1 E7HT UK.ORCID https://orcid.org/0000-0003-4147-0693
John M KellyDepartment of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine Keppel Street London WC1 E7HT UK.ORCID https://orcid.org/0000-0003-4305-5258
Ioannis P PapanastasiouDivision of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens Panepistimiopoli-Zografou 157 71 Athens Greece papanastasiou@pharm.uoa.gr.ORCID https://orcid.org/0000-0001-6974-2561

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, we describe the design, synthesis and evaluation of novel functionalised 1-(4-phenyl)adamantane and 1-(4-phenoxyphenyl)adamantane derivatives. Based on previous findings, we incorporated a phenyl ring between the adamantane core and the pharmacophoric side chain to enhance the activity and selectivity index (SI). The aromatic imidazolines 1a-d and the linear amidines 2a,b and 3a,b exhibited notable activity against

Identifiers

PMID40337307
PMCPMC12053444

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.