ArticleRespirology case reports2025
Sotorasib Is Not Effective in a KRAS-Mutated Patient With Brain Metastases From Lung Adenocarcinoma due to Multiple Gene Co-Mutations.
Article in Respirology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
A 60-year-old man diagnosed with lung adenocarcinoma underwent standard left lower lobectomy. However, he developed brain metastasis 10 months later, and the metastatic lesion was resected surgically. At that time, the KRAS G12C mutation was detected in the metastatic tissue by the Oncomine Dx Target Test. After 16 months, liver metastases appeared, and treatment with sotorasib was initiated. Unexpectedly, however, Sotorasib was ineffective, and the disease progressed. Cancer Genome Profiling (CGP) Test revealed that mutations of
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