Evidence map›Paper›PMID 40337253›Full record

ArticleJournal of clinical and experimental hepatology

Living Donor Liver Transplantation for Pediatric Wilson's Disease-related Acute Liver Failure-Hard Work With High Rewards.

Somashekara H Ramakrishna, Vellaichamy Katheresan, Mohan B Kasala, Karnan Perumal, Selvakumar Malleeswaran, Joy Varghese, Rajanikanth V Patcha, Prashant Bachina, Poushya S Madhavapeddy, Mettu S Reddy

Abstract read
In one paragraph

Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Somashekara H RamakrishnaDepartment of Pediatric Hepatology & Transplant Hepatology, Rainbow Children's Hospital, Marathahalli, Bangalore, India.
Vellaichamy KatheresanDepartment of Liver Transplant and Hepatopancreaticobiliary Surgery, Gleneagles Global Health City, Perumbakkam, Chennai, India.
Mohan B KasalaDepartment of Pediatric Intensive Care, Gleneagles Global Health City, Perumbakkam, Chennai, India.
Karnan PerumalDepartment of Pediatric Intensive Care, Gleneagles Global Health City, Perumbakkam, Chennai, India.
Selvakumar MalleeswaranDepartment of Liver Anesthesia and Critical Care, Gleneagles Global Health City, Perumbakkam, Chennai, India.
Joy VargheseDepartment of Hepatology, Gleneagles Global Health City, Perumbakkam, Chennai, India.
Rajanikanth V PatchaDepartment of Liver Transplant and Hepatopancreaticobiliary Surgery, Gleneagles Global Health City, Perumbakkam, Chennai, India.
Prashant BachinaDepartment of Pediatric Gastroenterology, Rainbow Children's Hospitals, Banjara Hills, Hyderabad, India.
Poushya S MadhavapeddyDepartment of Pediatric Gastroenterology, Rainbow Children's Hospitals, Banjara Hills, Hyderabad, India.
Mettu S ReddyDepartment of Liver Transplant and Hepatopancreaticobiliary Surgery, Gleneagles Global Health City, Perumbakkam, Chennai, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Liver transplantation (LT) is indicated for children with Wilson's disease (WD) presenting with acute liver failure (ALF) or with chronic liver disease (CLD) that has progressed to decompensation. We present our experience of living donor liver transplantation (LDLT) for pediatric WD, discuss the challenges of managing WD-ALF and compare outcomes of children presenting with WD-ALF with WD-CLD. Methods: We compared presentation and outcomes of the WD-ALF and WD-CLD cohorts. Fifty-three children (WD-ALF: 28 (53%), WD-CLD: 25 (47%)) underwent LDLT for WD. Results: WD-ALF group had higher Kings New Wilson Index (KNWI) (15 vs 9, Conclusion: LDLT is a curative treatment for children with WD with excellent short-term and long-term outcomes. WD-ALF patients can have a complicated postoperative course but have good long-term survival.

Indexed as

acute liver failurechildrenfungal infectionsliver transplantationliving donorrenal replacement therapytherapeutic plasma exchangeWilson’s disease

Identifiers

PMID40337253
PMCPMC12053706

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.