Evidence map›Paper›PMID 40337248›Full record

ArticleClinical parkinsonism & related disorders2025

Retinal microvascular and microcirculatory responses related to cognition improvement following yoga training in patients with Parkinson's disease.

Hong Jiang, Kirill Stremousov, Yunhai Dai, Bonnie Levin, Amanda Virgets, Andrew Hoover, Kylie J Martinez, Joseph Signorile, Jianhua Wang

Abstract read
In one paragraph

Article in Clinical parkinsonism & related disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hong JiangDepartment of Ophthalmology, Bascom Palmer Eye Institute, Miami, FL 33136, USA.
Kirill StremousovDepartment of Ophthalmology, Bascom Palmer Eye Institute, Miami, FL 33136, USA.
Yunhai DaiDepartment of Ophthalmology, Bascom Palmer Eye Institute, Miami, FL 33136, USA.
Bonnie LevinDepartment of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Amanda VirgetsDepartment of Kinesiology and Sports Sciences, University of Miami, Miami, FL 33124, USA.
Andrew HooverDepartment of Ophthalmology, Bascom Palmer Eye Institute, Miami, FL 33136, USA.
Kylie J MartinezDepartment of Kinesiology and Sports Sciences, University of Miami, Miami, FL 33124, USA.
Joseph SignorileDepartment of Kinesiology and Sports Sciences, University of Miami, Miami, FL 33124, USA.
Jianhua WangDepartment of Ophthalmology, Bascom Palmer Eye Institute, Miami, FL 33136, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To determine the relationship of retinal microcirculatory responses to cognitive function following yoga training in patients with Parkinson's disease (PD). Methods: Twenty patients with diagnosed PD were recruited, and retinal imaging was successful on 17 patients (age 71.8 ± 7.2 years old, nine females). Retinal capillary perfusion density (CPD) was imaged using optical coherence tomography angiography (OCTA), and retinal blood flow (RBF) was imaged using a retinal function imager (RFI). All patients participated in three 1-hour YogaCue or Hatha yoga classes per week for 24 consecutive weeks. Pearson correlation analyses determined the relationship between the changes in retinal microcirculatory responses and cognitive function. Results: Increased RBF was significantly related to the changes of CPD in all retinal slabs, including superficial and deeper vascular plexuses and retinal vascular network (6 mm scan, r ranged 0.58-0.83, P < 0.05). The increased RBF and CPD of superficial vascular plexus (6 mm scan) were related to the improvements (i.e., shorter time) in trail-making A performance (r = -0.66, P < 0.01 and r = -0.58, P < 0.05, respectively). In addition, the change of CPD in the retinal vascular network was related to improvement in Hopkins verbal delayed recall (r = 0.50, P < 0.05). Conclusion: This is the first study exploring the relationship between retinal microcirculatory responses to yoga exercise and cognitive function in PD patients. The synergistic effect of CPD and RBF may be developed into ocular indicators for monitoring the effect of cognitive improvement from yoga exercise in patients with PD.

Indexed as

Capillary densityCognitive functionMicrocirculationParkinson’s diseaseRetinaRetinal blood flowYoga

Identifiers

PMID40337248
PMCPMC12056766

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.